Mutations of ferric uptake regulator (fur) impair iron homeostasis, growth, oxidative stress survival, and virulence of Xanthomonas campestris pv. campestris

被引：0
作者：
Thichakorn Jittawuttipoka
Ratiboot Sallabhan
Paiboon Vattanaviboon
Mayuree Fuangthong
Skorn Mongkolsuk
机构：
[1] Mahidol University,Department of Biotechnology
[2] Mahidol University,Center of Emerging Bacterial Infection, Faculty of Science
[3] Chulabhorn Research Institute,Laboratory of Biotechnology
[4] Chulabhorn Graduate Institute,undefined
[5] Center of Excellence on Environmental Health,undefined
[6] Toxicology and Management of Chemicals,undefined
来源：
Archives of Microbiology | 2010年 / 192卷
关键词：
Fur; Iron; Plant pathogen; Ferric uptake regulator;
D O I：
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中图分类号：
学科分类号：
摘要：
Iron is essential in numerous cellular functions. Intracellular iron homeostasis must be maintained for cell survival and protection against iron’s toxic effects. Here, we characterize the roles of Xanthomonas campestris pv. campestris (Xcc) fur, which encodes an iron sensor and a transcriptional regulator that acts in iron homeostasis, oxidative stress, and virulence. Herein, we isolated spontaneous Xcc fur mutants that had high intracellular iron concentrations due to constitutively high siderophore levels and increased expression of iron transport genes. These mutants also had reduced aerobic plating efficiency and resistance to peroxide killing. Moreover, one fur mutant was attenuated on a host plant, thus indicating that fur has important roles in the virulence of X. campestris pv. campestris.
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页码：331 / 339
页数：8
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