Recent advances in understanding Crohn’s disease

被引：0
作者：
Antonio Di Sabatino
Laura Rovedatti
Francesca Vidali
Thomas Thornton MacDonald
Gino Roberto Corazza
机构：
[1] University of Pavia,First Department of Medicine, Centro per lo Studio e la Cura delle Malattie Infiammatorie Croniche Intestinali, Fondazione IRCCS Policlinico S. Matteo
[2] Barts and the London School of Medicine and Dentistry,Centre for Immunology and Infectious Disease, Blizard Institute of Cell and Molecular Science
[3] Fondazione IRCCS Policlinico San Matteo,Clinica Medica I
来源：
Internal and Emergency Medicine | 2013年 / 8卷
关键词：
Chronic inflammation; Fistula; Inflammatory bowel disease; Stricture; Therapy;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
Crohn’s disease is a chronic inflammatory bowel disorder resulting from an inappropriate innate and acquired immune response to commensal microorganisms in genetically susceptible individuals. This disease has a fluctuating course, with alternating periods of remission and relapses, and it is characterized by a remarkable clinical heterogeneity; it may be complicated by perianal fistulas, abscesses, and intestinal strictures leading to obstructions, besides several systemic manifestations. However, a complete resolution of the disease is currently not possible, yet Crohn’s disease can be managed with established and novel therapies, which achieve long-term remission and acceptable quality of life. This review is focused on novel advances in basic and clinical aspects of Crohn’s disease, although it also deals with new trends in diagnosis and treatment.
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页码：101 / 113
页数：12
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[1]  
Hou JK(2009)Distribution and manifestations of inflammatory bowel disease in Asians, Hispanics, and African Americans: a systematic review Am J Gastroenterol 104 2100-2109
[2]  
El-Serag H(1990)Crohn’s disease in Ashkenazi Jews Gastroenterology 99 286-287
[3]  
Thirumurthi S(2008)Disorders of a modern lifestyle: reconciling the epidemiology of inflammatory bowel diseases Gut 57 1185-1191
[4]  
Zlotogora J(2004)Clinical epidemiology of inflammatory bowel disease: incidence, prevalence, and environmental influences Gastroenterology 126 1504-1517
[5]  
Zimmerman J(2006)Family and twin studies in inflammatory bowel disease World J Gastroenterol 12 3668-3672
[6]  
Rachmilewitz D(2010)Genome-wide meta-analysis increases to 71 the number of confirmed Crohn’s disease susceptibility loci Nat Genet 42 1118-1125
[7]  
Bernstein CN(2001)A frameshift mutation inNOD2 associated with susceptibility to Crohn’s disease Nature 411 603-606
[8]  
Shanahan F(2008)The molecular basis of NOD2 susceptibility mutations in Crohn’s disease Mucosal Immunol 1 S5-S9
[9]  
Loftus EV(2009)Update on genetics in inflammatory disease Best Pract Res ClinGastroenterol 23 233-243
[10]  
Halme L(2009)Susceptibility genes and overall pathogenesis of inflammatory bowel disease: where do we stand? Dig Dis 27 226-235
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