18F-fluoro-deoxyglucose positron emission tomography/computed tomography scan findings in Rosai-Dorfman disease with IgG4-positive plasma cell infiltration mimicking breast malignancy: A case report and literature review

被引：8

作者：

Fu L. ^{[1
]}

Liu M. ^{[2
]}

Song Z. ^{[2
]}

Xu B. ^{[1
]}

Tian J. ^{[1
]}

机构：

[1] Department of Nuclear Medicine, Chinese PLA General Hospital, PLA Medical School, Beijing, 100853

[2] Department of Pathology, Chinese PLA General Hospital, PLA Medical School, Beijing, 100853

来源：

Journal of Medical Case Reports | / 6卷 / 1期

基金：

中国博士后科学基金; 中国国家自然科学基金;

关键词：

Amyloidosis; IgG4-related sclerosing disease; Position emission tomography; Rosai-Dorfman disease;

D O I：

10.1186/1752-1947-6-411

中图分类号：

学科分类号：

摘要：

Introduction. Rosai-Dorfman disease, also known as sinus histiocytosis with massive lymphadenopathy, is a rare benign disorder characterized histologically by lymphatic sinus dilatation due to histiocyte proliferation. Rosai-Dorfman disease accompanied by IgG4+ plasma cell infiltration is an even rarer situation. To the best of our knowledge, no imaging report of fluoro-deoxyglucose positron emission tomography/computed tomography findings of Rosai-Dorfman disease with IgG4+ plasma cell infiltration has been published, although a series of pathological research has focused on this phenomenon. Case presentation. We reviewed the 18F-fluoro- deoxyglucose positron emission tomography/computed tomography scan of a 78-year-old Chinese woman with a solid mass that was found in her right breast during a health checkup. 18F-fluoro-deoxyglucose positron emission tomography/computed tomography showed a hypermetabolic nodule in her right breast and slightly heterogeneous increased fluoro-deoxyglucose uptake of the pulmonary nodules, which were histologically proven to be mammary Rosai-Dorfman disease with IgG4+ plasma cell infiltration and pulmonary amyloidosis, respectively. A literature review was performed to gather information on this rare disease process. Conclusions: Although distinguishing benign lymphoplasmacytic proliferation from malignancy may be difficult with 18F-fluoro-deoxyglucose positron emission tomography/computed tomography in light of the pattern and intensity of fluoro-deoxyglucose uptake, our case highlights that whole-body positron emission tomography/computed tomography imaging not only can display the extent of the disease to help complete staging but also can provide functional information about disease activity to guide biopsy. © 2012 Fu et al.; licensee BioMed Central Ltd.

引用

共 18 条

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