The transcription factor Sox4 is a downstream target of signaling by the cytokine TGF-β and suppresses TH2 differentiation

被引：0
作者：
Makoto Kuwahara
Masakatsu Yamashita
Kenta Shinoda
Soichi Tofukuji
Atsushi Onodera
Ryo Shinnakasu
Shinichiro Motohashi
Hiroyuki Hosokawa
Damon Tumes
Chiaki Iwamura
Veronique Lefebvre
Toshinori Nakayama
机构：
[1] Graduate School of Medicine,Department of Immunology
[2] Chiba University,Department of Human Genome Research
[3] Laboratory of Medical Genomics,Department of Cell Biology and Orthopedic Research Center
[4] Kazusa DNA Research Institute,undefined
[5] Japan Science and Technology Agency,undefined
[6] Precursory Research for Embryonic Science and Technology,undefined
[7] Lerner Research Institute,undefined
[8] Cleveland Clinic,undefined
[9] Japan Science and Technology Agency,undefined
[10] Core Research for Evolutional Science and Technology,undefined
来源：
Nature Immunology | 2012年 / 13卷
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学科分类号：
摘要：
The mechanisms of TGF-β-mediated inhibition of TH2 differentiation remain unclear. Nakayama and colleagues show that TGF-β induces the transcription factor Sox4, which negatively regulates the transcription factor GATA-3 by two independent mechanisms.
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页码：778 / 786
页数：8
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