Formyl peptide receptor 2 as a potential therapeutic target for inflammatory bowel disease

被引：0
作者：
Wen-sheng Yang
Jing-lin Wang
Wei Wu
Guang-fei Wang
Jun Yan
Qing Liu
Xiao-yan Wu
Qing-tong Zhou
De-hua Yang
Ming-Wei Wang
Zhi-ping Li
机构：
[1] National Children’s Medical Center,Department of Pharmacy, Children’s Hospital of Fudan University
[2] Huazhong University of Science and Technology,Department of Pharmacy, Union Hospital, Tongji Medical College
[3] Fudan University,Department of Laboratory Animal Science
[4] Chinese Academy of Sciences,The National Center for Drug Screening, Shanghai Institute of Materia Medica
[5] Research Center for Deepsea Bioresources,Department of Pharmacology, School of Basic Medical Sciences
[6] Fudan University,undefined
来源：
Acta Pharmacologica Sinica | 2023年 / 44卷
关键词：
resolution; inflammation; FPR2/ALX; SPM; IBD; pro-resolving;
D O I：
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学科分类号：
摘要：
Inflammatory bowel disease (IBD) is a global health burden whose existing treatment is largely dependent on anti-inflammatory agents. Despite showing some therapeutic actions, their clinical efficacy and adverse events are unacceptable. Resolution as an active and orchestrated phase of inflammation involves improper inflammatory response with three key triggers, specialized pro-resolving mediators (SPMs), neutrophils and phagocyte efferocytosis. The formyl peptide receptor 2 (FPR2/ALX) is a human G protein-coupled receptor capable of binding SPMs and participates in the resolution process. This receptor has been implicated in several inflammatory diseases and its association with mouse model of IBD was established in some resolution-related studies. Here, we give an overview of three reported FPR2/ALX agonists highlighting their respective roles in pro-resolving strategies.
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页码：19 / 31
页数：12
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[101]  
Levy BD(2021)Resolvin D1 suppresses inflammation-associated tumorigenesis in the colon by inhibiting IL-6-induced mitotic spindle abnormality FASEB J 35 1694-64
[102]  
Serhan CN(2017)Protectin d1n-3 DPA and resolvin D5n-3 DPA are effectors of intestinal protection Proc Natl Acad Sci USA 114 501-49
[103]  
Yang R(2020)Maresin 1 alleviates dextran sulfate sodium-induced ulcerative colitis by regulating NRF2 and TLR4/NF-kB signaling pathway Int Immunopharmacol 78 3706-76
[104]  
Martinod K(2009)International union of basic and clinical pharmacology. LXXIII. Nomenclature for the formyl peptide receptor (FPR) family Pharmacol Rev 61 49-704
[105]  
Kasuga K(2020)Formyl peptide receptors in the mucosal immune system Exp Mol Med 52 2776-806
[106]  
Pillai PS(2006)Formyl peptide receptors: A promiscuous subfamily of G protein-coupled receptors controlling immune responses Cytokine Growth Factor Rev 17 346-407
[107]  
Porter TF(2021)The role of formyl peptide receptors in permanent and low-grade inflammation: Helicobacter pylori infection as a model Int J Mol Sci 22 615-50
[108]  
Serhan CN(2016)Mitochondrial n-formyl peptides cause airway contraction and lung neutrophil infiltration via formyl peptide receptor activation Pulm Pharmacol Ther 37 4891-97
[109]  
Petasis NA(2018)Garcinia multiflora inhibits FPR1-mediated neutrophil activation and protects against acute lung injury Cell Physiol Biochem 51 C939-13
[110]  
Serhan CN(2019)G-protein-coupled formyl peptide receptors play a dual role in neutrophil chemotaxis and bacterial phagocytosis Mol Biol Cell 30 105117-99
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