NLRP3 Inflammasome Inhibitor OLT1177 Suppresses Onset of Inflammation in Mice with Dextran Sulfate Sodium-Induced Colitis

[1] Podolsky DK(2002)Inflammatory bowel disease N Engl J Med. 347 417-429

[2] Goyette P(2007)Molecular pathogenesis of inflammatory bowel disease: genotypes, phenotypes and personalized medicine Ann Med. 39 177-199

[3] Labbé C(2007)Intracellular NOD-like receptors in host defense and disease Immunity. 27 549-559

[4] Trinh TT(2011)Sensing damage by the NLRP3 inflammasome Immunol Rev. 243 152-162

[5] Xavier RJ(2008)The NLR gene family: a standard nomenclature Immunity. 28 285-287

[6] Rioux JD(2012)IL-1β mediates chronic intestinal inflammation by promoting the accumulation of IL-17A secreting innate lymphoid cells and CD4(+) Th17 cells J Exp Med. 209 1595-1609

[7] Kanneganti TD(2010)Colitis induced in mice with dextran sulfate sodium (DSS) is mediated by the NLRP3 inflammasome Gut. 59 1192-1199

[8] Lamkanfi M(2019)NEK7 interacts with NLRP3 to modulate the pyroptosis in inflammatory bowel disease via NF-κB signaling Cell Death Dis. 10 906-1539

[9] Núñez G(2018)OLT1177, a β-sulfonyl nitrile compound, safe in humans, inhibits the NLRP3 inflammasome and reverses the metabolic cost of inflammation Proc Natl Acad Sci U S A. 115 E1530-59

[10] Leemans JC(2019)OLT1177 (Dapansutrile), a Selective NLRP3 Inflammasome Inhibitor, Ameliorates Experimental Autoimmune Encephalomyelitis Pathogenesis Front Immunol. 10 2578-937

[1] Podolsky DK(2002)Inflammatory bowel disease N Engl J Med. 347 417-429

[2] Goyette P(2007)Molecular pathogenesis of inflammatory bowel disease: genotypes, phenotypes and personalized medicine Ann Med. 39 177-199

[3] Labbé C(2007)Intracellular NOD-like receptors in host defense and disease Immunity. 27 549-559

[4] Trinh TT(2011)Sensing damage by the NLRP3 inflammasome Immunol Rev. 243 152-162

[5] Xavier RJ(2008)The NLR gene family: a standard nomenclature Immunity. 28 285-287

[6] Rioux JD(2012)IL-1β mediates chronic intestinal inflammation by promoting the accumulation of IL-17A secreting innate lymphoid cells and CD4(+) Th17 cells J Exp Med. 209 1595-1609

[7] Kanneganti TD(2010)Colitis induced in mice with dextran sulfate sodium (DSS) is mediated by the NLRP3 inflammasome Gut. 59 1192-1199

[8] Lamkanfi M(2019)NEK7 interacts with NLRP3 to modulate the pyroptosis in inflammatory bowel disease via NF-κB signaling Cell Death Dis. 10 906-1539

[9] Núñez G(2018)OLT1177, a β-sulfonyl nitrile compound, safe in humans, inhibits the NLRP3 inflammasome and reverses the metabolic cost of inflammation Proc Natl Acad Sci U S A. 115 E1530-59

[10] Leemans JC(2019)OLT1177 (Dapansutrile), a Selective NLRP3 Inflammasome Inhibitor, Ameliorates Experimental Autoimmune Encephalomyelitis Pathogenesis Front Immunol. 10 2578-937