Red emissive boron and nitrogen co-doped “on-off-on” carbon dots for detecting and imaging of mercury(II) and biothiols

被引：0
作者：
Lan-Fang Pang
Hao Wu
Meng-Jie Fu
Xiao-Feng Guo
Hong Wang
机构：
[1] Wuhan University,Key Laboratory of Analytical Chemistry for Biology and Medicine (Ministry of Education), College of Chemistry and Molecular Sciences
来源：
Microchimica Acta | 2019年 / 186卷
关键词：
Red emitting; Fluorescence probe; Nanomaterial; Fluorescence turn-off-on system; Biothiols; Cell imaging;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
Red emissive B,N co-doped carbon dots (BN-CDs) were hydrothermally synthesized from cresyl violet and boric acid. The BN-CDs exhibited excellent photostability, low cytotoxicity, excitation/emission maxima at 520/616 nm, and a relatively high quantum yield of 18%. The BN-CDs can binded to mercury(II), and this results in quenching of the red-colored fluorescence. However, on subsequent addition of the biothiol (such as cysteine, homocysteine or glutathione), fluorescence recovers. Therefore, the BN-CDs can be used as a multifunctional probe based on “on-off-on” fluorescence response for the detection of Hg(II) and biothiols. The following detection limits were accomplished: (a) Hg(II): 2.8 μM; (b) glutathione: 1.7 μM; (c) cysteine: 2.3 μM; (d) homocysteine: 3.0 μM. The BN-CDs also have been successfully applied for the imaging of Hg(II) and biothiols in HepG2 cells with excellent bio-compatibility.
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