Hybrid tracers and devices for intraoperative imaging: the future for radioguided surgery?

被引：11
作者：
Gambini J.P. [1 ]
Quinn T.P. [2 ]
机构：
[1] Centro de Medicina Nuclear e Imagenología Molecular, Hospital de Clínicas, Universidad de la República, Avda. Italia s/n, Montevideo
[2] Biochemistry Department, 117 Schweitzer Hall, University of Missouri, Columbia, 65211, MO
来源：
Clinical and Translational Imaging | 2016年 / 4卷 / 5期
关键词：
!sup]99m[!/sup]Tc nanocolloid-indocyanine green; GHOST; GOSTT; Hybrid tracers; Radioguided surgery;
D O I：
10.1007/s40336-016-0198-3
中图分类号：
学科分类号：
摘要：
Radioguided surgery (RS) allows surgeons to identify tissues of interest that were preoperatively or intraoperatively marked with radiotracers. This discipline has seen major changes related to the development of new tracers, instrumentation and software. The goal of this review is to comment on current development and perspectives in the RS field. The review is based on published papers that highlight the role of RS and explore current advances such as the Guided intraOperative Scintigraphic Tumour Targeting (GOSTT) concept, which established the see, open and see strategy and propose a new one, Guided Hybrid intraOperative Specific Targeting (GHOST). We examine the development of radioactive, fluorescent and hybrid tracers and corresponding instrumentation and software to detect them and suggest ways in which these developments could be integrated. The role of hybrid tracers in RS, in particular 99mTc nanocolloid indocyanine green on sentinel node procedures, is highlighted. Labeled specific targeted peptides, antibodies and nanostructures will allow better preoperative diagnosis and intraoperative localization of tissue of interest. Photodynamic therapy could be applied during surgery to eliminate residual tumoral tissue. In the follow up, patients could be considered for treatment with targeted radiotherapy. RS has moved from open surgery to laparoscopic and robotic surgery. In each of them it is possible to add fluorescent, radioactive and hybrid modules able to detect labeled tissue of interest, while preserving healthy ones. As we have seen, RS is advancing through an interdisciplinary collaboration that will provide surgeons with new tools to improve surgical outcomes. © 2016, Italian Association of Nuclear Medicine and Molecular Imaging.
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收藏
页码：343 / 351
页数：8
相关论文
共 68 条
  • [1] Zaknun J.J., Giammarile F., Valdes Olmos R.A., Vidal-Sicart S., Mariani G., Changing in radioguided surgery and intraoperative imaging: the GOSTT concept, Eur J Nucl Med Mol Imaging, 39, pp. 1-3, (2012)
  • [2] Valdes Olmos R.A., Vidal-Sicart S., Giammarile F., Zaknun J.J., Van Leeuwen F.W., Mariani G., The GOSTT concept and hybrid mixed/virtual/augmented reality environment radioguided surgery, Q J Nucl Med Mol Imaging, 58, 2, pp. 207-215, (2014)
  • [3] Ikeda Y., Takayama J., Takami H., Minimally invasive radioguided parathyroidectomy for hyperparathyroidism, Ann Nucl Med, 24, 4, pp. 233-240, (2010)
  • [4] Garcia-Talavera P., Ruano R., Riojac M.E., Cordero J.M., Razola P., Vidal-Sicart S., Radioguided surgery in neuroendocrine tumors. A review of the literature, Rev Esp Med Nucl Imagen Mol, 33, 6, pp. 358-365, (2014)
  • [5] Moncayo V.M., Aarsvold J.N., Alazraki N.P., Lymphoscintigraphy and sentinel nodes, J Nucl Med, 56, 6, pp. 901-907, (2015)
  • [6] Liu Z., Niu G., Wang F., Chen X., (68)Ga-labeled NOTA-RGD-BBN peptide for dual integrin and GRPR-targeted tumor imaging, Eur J Nucl Med Mol Imaging, 36, 9, pp. 1483-1494, (2009)
  • [7] Wang W., Ke S., Kwon S., Yallampalli S., Cameron A.G., Adams K.E., Mawad M.E., Sevick-Muraca E.M., A new optical and nuclear dual-labeled imaging agent targeting interleukin 11 receptor alpha-chain, Bioconjug Chem, 18, 2, pp. 397-402, (2007)
  • [8] Alander J.T., Kaartinen I., Laakso A., Patila T., Spillmann T., Tuchin V.V., Venermo M., Valisuo P., A review of indocyanine green fluorescent imaging in surgery, Int J Biomed Imaging, 2012, (2012)
  • [9] Zelken J.A., Tufaro A.P., Current trends and emerging future of indocyanine green usage in surgery and oncology: an update, Ann Surg Oncol, 22, 3, pp. 1271-1283, (2015)
  • [10] Lozano N., Al-Ahmady Z.S., Beziere N.S., Ntziachristos V., Kostarelos K., Monoclonal antibody-targeted PEGylated liposome ICG encapsulating doxorubicin as a potential theranostic agent, Int J Pharm, 482, 1-2, pp. 2-10, (2015)
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