Influence of retinol deficiency and curcumin/turmeric feeding on tissue microsomal membrane lipid peroxidation and fatty acids in rats

被引：0
作者：
Sangeeta Kaul
T.P. Krishnakantha
机构：
[1] Central Food Technological Research Institute,Department of Biochemistry and Nutrition
来源：
Molecular and Cellular Biochemistry | 1997年 / 175卷
关键词：
retinol deficiency; lipid peroxidation; fatty acids; curcumin; turmeric; microsomes; membrane;
D O I：
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摘要：
The effect of retinol deficiency and curcumin/turmeric on lipid peroxidation and fatty acid profile was studied in liver, kidney, spleen and brain microsomes of rats. Results revealed an increase in lipid peroxidation in retinol deficient liver by 32%, kidney 30%, spleen 24% and brain 43% compared to the controls. Feeding 0.1% curcumin or turmeric for three weeks in diet to retinol deficient rats reduced the lipid peroxidation respectively to 12.5 or 22.6%, in liver, 23.7 or 24.1% in kidney, 14.4 or 18.0% spleen and 16.0 or 31.4% in brain. Retinol deficiency lead to a reduction in the essential fatty acids. In liver C18:1 showed a reduction by 45.6%, C18:2 by 31.6% and C20:4 by 22.8%. In kidney C18:1 was reduced by 33.6%, 18:2 by 24.6% and 20:4 by 13.7%. In spleen and brain C18:1 showed a reduction by 10.2% and 33.9%, C18:2 by 37.9% and 12.1% and C20:4 by 15.7% and 35.3% respectively. Curcumin and turmeric fed group showed a significant increase in the abnormally reduced fatty acid levels. (Mol Cell Biochem 175: 43–48, 1997)
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页码：43 / 48
页数：5
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共 93 条
  • [1] Weber F(1983)Biochemical mechanisms of vitamin-A action Proc Nutr Soc 42 31-40
  • [2] Giguere V(1987)Identification of receptor for the morphogen retinoic acid Nature 330 624-629
  • [3] Ong ES(1987)Intracellular vitamin-A binding proteins Ann Rev Nutr 7 321-335
  • [4] Segui P(1991)Dietary vitamin-A deficiency: Effects on growth, infection and mortality Food and Nutr Bull 13 119-131
  • [5] Evanes RM(1972)The occurrence of vitamin-A in biological membranes Biochim Biophys Acta 288 203-219
  • [6] Chytil F(1991)The influence of dietary Vitamin-A intake on microsomal membrane fluidity and lipid composition Nutr Res 11 567-574
  • [7] Ong DE(1985)Evidence for two subcellular pools and different kinetic behaviour of retinyl palmitate in rat liver Internat J Vit Nutr Res 55 245-251
  • [8] West KP(1993)Stimulation of Fe induced lipid peroxidation in phosphatidylcholine liposomes by aluminium ions at physiological pH Biochim Biophys Acta 1170 182-188
  • [9] Mack JP(1993)Dietary J Nutr Sci Vitaminol 39 345-354
  • [10] Lui NST(1987) increases mitogenic response of splenic lymphocytes in mice Nutr Rep Internat 36 573-580
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