A mouse model for embryonal tumors with multilayered rosettes uncovers the therapeutic potential of Sonic-hedgehog inhibitors

被引：0

作者：

Julia E Neumann

Annika K Wefers

Sander Lambo

Edoardo Bianchi

Marie Bockstaller

Mario M Dorostkar

Valerie Meister

Pia Schindler

Andrey Korshunov

Katja von Hoff

Johannes Nowak

Monika Warmuth-Metz

Marlon R Schneider

Ingrid Renner-Müller

Daniel J Merk

Mehdi Shakarami

Tanvi Sharma

Lukas Chavez

Rainer Glass

Jennifer A Chan

M Mark Taketo

Philipp Neumann

Marcel Kool

Ulrich Schüller

机构：

[1] Center for Neuropathology,Department of Neuropathology

[2] Ludwig-Maximilians-University,Division of Pediatric Neuro

[3] Institute of Neuropathology,Oncology

[4] University Medical Center Hamburg-Eppendorf,Department of Pediatric Hematology and Oncology

[5] Research Institute Children's Cancer Center Hamburg,Department of Diagnostic and Interventional Radiology

[6] Ruprecht-Karls-University Heidelberg,Department of Pathology & Laboratory Medicine

[7] Clinical Cooperation Unit Neuropathology,Division of Experimental Therapeutics

[8] German Cancer Research Center (DKFZ),Department of Informatics

[9] German Cancer Consortium (DKTK),Department of Pediatric Hematology and Oncology

[10] Core Center Heidelberg,Cancer Biology and Pediatric Oncology

[11] German Cancer Research Center (DKFZ),undefined

[12] German Center for Neurodegenerative Diseases,undefined

[13] HIT-MED Study Center,undefined

[14] University Medical Center Hamburg-Eppendorf,undefined

[15] Reference Center for Neuroradiology,undefined

[16] University Hospital of Würzburg,undefined

[17] University Hospital of Würzburg,undefined

[18] Molecular Animal Breeding and Biotechnology,undefined

[19] Gene Center,undefined

[20] Ludwig-Maximilians-University,undefined

[21] Walter Brendel Center,undefined

[22] Ludwig-Maximilians-University,undefined

[23] Neurosurgical Research,undefined

[24] Ludwig-Maximilians-University,undefined

[25] University of Calgary,undefined

[26] Graduate School of Medicine,undefined

[27] Kyoto University,undefined

[28] University of Hamburg,undefined

[29] University Medical Center Hamburg-Eppendorf,undefined

[30] Dana–Farber Cancer Institute,undefined

来源：

Nature Medicine | 2017年 / 23卷

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摘要：

Simultaneous activation of Wnt and Shh pathways in murine neural precursor cells results in the formation of embryonal tumors with multilayered rosettes (ETMR) that recapitulate the histological and molecular features of human tumors. This novel mouse model represents a platform for evaluating therapeutic approaches for this rare malignant pediatric brain tumor, and provides novel insights into the cell of origin and molecular mechanisms driving the disease.

引用

页码：1191 / 1202

页数：11

共 102 条

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