An Assessment of the Incidence of Prolonged Postoperative Bleeding After Dental Extraction Among Patients on Uninterrupted Low Dose Aspirin Therapy and to Evaluate the Need to Stop Such Medication Prior to Dental Extractions

被引:113
作者
Eapen B.V. [1 ]
Baig M.F. [1 ]
Avinash S. [1 ]
机构
[1] Department of Oral and Maxillofacial Surgery, Saveetha Dental College, Saveetha University, Chennai
关键词
Bleeding time; Low-dose aspirin; Postoperative bleeding;
D O I
10.1007/s12663-016-0912-8
中图分类号
学科分类号
摘要
Purpose: To propose that low dose aspirin therapy need not be withdrawn for routine dental extraction procedure. Aim: This study was designed to evaluate the post operative bleeding in patients on low dose aspirin therapy by dividing them into two groups: one with withdrawing and the other without withdrawing the regime before dental extraction. Materials and Methods: This study included 80 patients on low dose aspirin therapy. They were divided into two groups of 40 patients each; Group I (control group) included patients on who were asked to stop the medication 5 days prior to dental extraction; Group II (test group) included patients who were asked not to stop the medication prior to dental extraction. Strict atraumatic extractions were performed by a single surgeon. Data were analyzed using the independent “t” test @ 80 % power. Results: The mean pre-operative bleeding time in the control group was 87.75 s and the test group was 95.75 s which was statistically significant (p < 0.05). The mean pre-operative clotting time in the control group was 228.63 s and the test group was 246.25 s which was also statistically significant (p < 0.05). No patients in either group had any episode of prolonged postoperative bleeding following extraction from the surgical site and no local haemostatic measures had to be used except for one patient in Group II. Conclusion: Authors conclude from this study that dental extraction procedures in patients on low-dose therapy can be safely carried out without stopping the antiplatelet therapy. © 2016, The Association of Oral and Maxillofacial Surgeons of India.
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页码:48 / 52
页数:4
相关论文
共 15 条
[1]  
Ardekian L., Gaspar R., Peled M., Et al., Does low-dose aspirin therapy complicate oral surgical procedures?, JADA, 131, pp. 331-335, (2000)
[2]  
Brennan M.T., Valerin M.A., Noll L.J., Napenas J.J., Kent M.L., Et al., Aspirin use and post-operative bleeding from dental extractions, J Dent Res, 87, 8, pp. 740-744, (2008)
[3]  
Cardona-Tortajada F., Sainz -Gomez E., Et al., Dental extractions in patients on antiplatelet therapy: a study conducted by the Oral Health Department of the Navarre Health Service (Spain), Med Oral Patol Oral Cir Bucal, 14, 11, pp. e588-e592, (2009)
[4]  
Krishnan B., Shenoy N., Alexander M., Exodontia and antiplatelet therapy, J Oral Maxillofac Surg, 66, pp. 2063-2066, (2008)
[5]  
Little J.W., Miller C.S., Henry R.G., Et al., Antithrombotic agents: implications in dentistry, OOOE, 93, pp. 544-551, (2002)
[6]  
Lockhart P.B., Gibson J., Pond S.H., Leitch J., Dental management considerations for the patient with an acquired coagulopathy. Part 2: Coagulopathies from drugs, Br Dent J, 195, 9, pp. 405-501, (2003)
[7]  
Madan G.A., Madan S.G., Madan G., Madan A.D., Minor oral surgery without stopping daily low-dose aspirin therapy: a study of 51 patients, J Oral Maxillofac Surg, 63, pp. 1262-1265, (2005)
[8]  
Sonksen J.R., Kong K.L., Holder R., Magnitude and time course of impaired primary haemostasis after stopping chronic low and medium dose aspirin in healthy volunteers, Br J Anaesth, 82, pp. 360-365, (1999)
[9]  
Valerin M.A., Brennan M.T., Napenas J.J., Et al., Relationship between aspirin use and post operative bleeding from dental extractions in a healthy population, OOOE, 102, (2006)
[10]  
Collaborative overview of randomized trials of antiplatelet therapy: prevention of death, myocardial infarction, and stroke by prolonged antiplatelet therapy in various categories of patients, Br Med J Clin Res, 308, (1994)