Structure-activity Relationships of Xanthocillin Derivatives as Thrombopoietin Receptor Agonist

被引：0
作者：
Takahiro Yamaguchi
Yumi Miyake
Atsushi Miyamura
Norihisa Ishiwata
Kuniaki Tatsuta
机构：
[1] School of Science and Engineering,Department of Chemistry
[2] Waseda University,undefined
[3] Biological Research Laboratories,undefined
[4] Nissan Chemical Industries,undefined
[5] Ltd.,undefined
来源：
The Journal of Antibiotics | 2006年 / 59卷
关键词：
xanthocillin; structure-activity relationships; anti-viral activities; thrombopoietin receptor agonist;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
Xanthocillin derivatives, which show thrombopoietin receptor agonist activity, were synthesized through our developed method. Bioassay data suggest the importance of alkene geometry, the presence of substituents at the benzene ring that support hydrophobic character, and the moderate size of the molecule. One of the two isonitrile group of the natural product appears to be dispensable.
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页码：729 / 734
页数：5
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