New advances of the androgen receptor in prostate cancer: report from the 1st International Androgen Receptor Symposium

被引：0
作者：
Sherif Mehralivand
Christian Thomas
Martin Puhr
Frank Claessens
Arjanneke F. van de Merbel
Anna Dubrovska
Guido Jenster
Christof Bernemann
Ulrich Sommer
Holger H. H. Erb
机构：
[1] University Hospital Carl Gustav Carus,Department of Urology, Faculty of Medicine
[2] Technische Universität Dresden,Department of Urology
[3] Medical University of Innsbruck,Molecular Endocrinology Laboratory, Department of Cellular and Molecular Medicine
[4] KU Leuven,Department of Urology
[5] Leiden University Medical Center,OncoRay
[6] Technische Universität Dresden and Helmholtz-Zentrum Dresden-Rossendorf,National Center for Radiation Research in Oncology, Faculty of Medicine and University Hospital Carl Gustav Carus
[7] Helmholtz-Zentrum Dresden-Rossendorf,Institute of Radiooncology
[8] National Center for Tumor Diseases (NCT),OncoRay
[9] German Cancer Research Center (DKFZ),Faculty of Medicine
[10] University Hospital Carl Gustav Carus,German Cancer Consortium (DKTK)
[11] Technische Universität Dresden,Department of Urology, Erasmus MC Cancer Institute
[12] Helmholtz-Zentrum Dresden-Rossendorf (HZDR),Department of Urology
[13] Partner Site Dresden and German Cancer Research Center (DKFZ),Institut für Pathologie, Medical Faculty
[14] University Medical Center,undefined
[15] University Hospital Muenster,undefined
[16] University Hospital Carl Gustav Carus,undefined
[17] Technische Universität Dresden,undefined
来源：
Journal of Translational Medicine | / 22卷
关键词：
Androgen receptor; PCa; NR3C4; Androgen deprivation therapy;
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摘要：
The androgen receptor (AR) is a crucial player in various aspects of male reproduction and has been associated with the development and progression of prostate cancer (PCa). Therefore, the protein is the linchpin of current PCa therapies. Despite great research efforts, the AR signaling pathway has still not been deciphered, and the emergence of resistance is still the biggest problem in PCa treatment. To discuss the latest developments in AR research, the “1st International Androgen Receptor Symposium” offered a forum for the exchange of clinical and scientific innovations around the role of the AR in prostate cancer (PCa) and to stimulate new collaborative interactions among leading scientists from basic, translational, and clinical research. The symposium included three sessions covering preclinical studies, prognostic and diagnostic biomarkers, and ongoing prostate cancer clinical trials. In addition, a panel discussion about the future direction of androgen deprivation therapy and anti-AR therapy in PCa was conducted. Therefore, the newest insights and developments in therapeutic strategies and biomarkers are discussed in this report.
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