Pancreatic Islet Transplantation Technologies: State of the Art of Micro- and Macro-Encapsulation

被引：0
作者：
Cantarelli E. [1 ]
Citro A. [1 ]
Piemonti L. [1 ,2 ]
机构：
[1] Diabetes Research Institute, IRCCS San Raffaele Scientific Institute, Via Olgettina 60, Milan
[2] Vita- Salute University, Milan
来源：
Current Transplantation Reports | 2017年 / 4卷 / 3期
关键词：
Capsule immunoprotection; Device fibrotic reaction; Islet encapsulation; Islet transplantation; Type; 1; diabetes;
D O I：
10.1007/s40472-017-0154-9
中图分类号：
学科分类号：
摘要：
Purpose of Review: Type 1 diabetes (T1D) is an autoimmune disease characterized by the loss of insulin-producing cells in pancreatic islets. Despite islet transplantation is effective for selected T1D patients, its widespread application is limited by islet donor shortage and the need for lifelong immunosuppression. Micro- and macro-encapsulation aimed at enveloping cells in a perm-selective biocompatible membrane can potentially eliminate these limitations. This review summarizes tissue-engineering approaches tested in preclinical models of islet transplantation, highlighting technologies currently in the clinic. Recent Findings: More than 40 years of intensive research raised promises and challenges. Ongoing clinical studies have not yet achieved the desired success as obstacles remained to be overcome: deleterious fibrotic response toward the biomaterial, poor vascularization, insufficient oxygen delivery, and recipient’s immune reaction. Summary: Only the joint effort of bioengineering, cell biology, and immunology expertises will foster the development of novel, effective, and safe technologies for insulin-producing cell transplantation. © 2017, Springer International Publishing AG.
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页码：169 / 183
页数：14
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