The true value of the true test for allergic contact dermatitis

被引：15
作者：
Fischer T. [1 ]
Kreilgård B. [1 ]
Maibach H.I. [1 ]
机构：
[1] Department of Dermatology, University of California-San Francisco School of Medicine, Box 0889, Surge 100, San Francisco, 04143-0989, CA
来源：
Current Allergy and Asthma Reports | 2001年 / 1卷 / 4期
关键词：
Contact Dermatitis; Patch Test; Allergic Contact Dermatitis; Lanolin; Patch Test Reaction;
D O I：
10.1007/s11882-001-0042-2
中图分类号：
学科分类号：
摘要：
The development of the thin layer rapid use epicutaneous (TRUE) Test is a history of cooperation between scientists from academia and industry covering several disciplines: medicine, pharmaceutical chemistry, pharmacology, and statistics. The TRUE Test is today a patch test system with documented stability and allergen content. Allergens are incorporated in a dried-in-gel vehicle, which is coated onto a polyester backing to form a patch. Applied to the skin, the allergens are released when the gel becomes moisturized by transepidermal water. This may seem to be a simple technique, but its development required laborious research and solutions to stability and dosage problems. The test has been clinically standardized with serial dilution tests on sensitized patients and validated in comparative multicenter tests. The test is a significant step towards higher reliability of patch testing. Fifteen years of experience and critical investigations are discussed in this article, as are possible improvements such as expansion of the test with new allergens. © 2001 by Current Science Inc.
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收藏
页码：316 / 322
页数：6
相关论文
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