An MRI atlas of the mouse basal ganglia

被引：0
作者：
Jeremy F. P. Ullmann
Charles Watson
Andrew L. Janke
Nyoman D. Kurniawan
George Paxinos
David C. Reutens
机构：
[1] The University of Queensland,The Australian Mouse Brain Mapping Consortium
[2] The University of Queensland,Center for Advanced Imaging
[3] Curtin University,Health Sciences
[4] The University of New South Wales,Neuroscience Research Australia
来源：
Brain Structure and Function | 2014年 / 219卷
关键词：
Basal ganglia; Pallidum; Striatum; Mouse brain; Atlas; Magnetic resonance imaging;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
The basal ganglia are a group of subpallial nuclei that play an important role in motor, emotional, and cognitive functions. Morphological changes and disrupted afferent/efferent connections in the basal ganglia have been associated with a variety of neurological disorders including psychiatric and movement disorders. While high-resolution magnetic resonance imaging has been used to characterize changes in brain structure in mouse models of these disorders, no systematic method for segmentation of the C57BL/6 J mouse basal ganglia exists. In this study we have used high-resolution MR images of ex vivo C57BL/6 J mouse brain to create a detailed protocol for segmenting the basal ganglia. We created a three-dimensional minimum deformation atlas, which includes the segmentation of 35 striatal, pallidal, and basal ganglia-related structures. In addition, we provide mean volumes, mean T2 contrast intensities and mean FA and ADC values for each structure. This MR atlas is available for download, and enables researchers to perform automated segmentation in genetic models of basal ganglia disorders.
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页码：1343 / 1353
页数：10
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