Effects of helminth co-infections on atopy, asthma and cytokine production in children living in a poor urban area in Latin America

被引：49

作者：

Alcantara-Neves N.M. ^{[1
,9
]}

Britto G.D.S.G. ^{[1
]}

Veiga R.V. ^{[1
]}

Figueiredo C.A. ^{[1
]}

Fiaccone R.L. ^{[2
,3
]}

Da Conceição J.S. ^{[3
]}

Cruz Á.A. ^{[4
]}

Rodrigues L.C. ^{[5
]}

Cooper P.J. ^{[6
,7
]}

Pontes-De-Carvalho L.C. ^{[8
]}

Barreto M.L. ^{[3
]}

机构：

[1] Departamento de Ciências da Biointeração, Instituto de Ciências da Saúde, Universidade Federal da Bahia, Salvador

[2] Instituto de Matemática, Universidade Federal da Bahia, Salvador

[3] Instituto de Saúde Coletiva, Universidade Federal da Bahia, Salvador

[4] ProAR - Nucleo de Excelência em Asma, Universidade Federal da Bahia, Salvador

[5] London School of Hygiene and Tropical Medicine, University of London, London

[6] Escuela de Biologia, Pontifícia Universidad Católica Del Ecuador, Quito

[7] Institute of Infection and Immunity, St George's University of London, London

[8] Centro de Pesquisas Gonçalo Moniz, Fundação Oswaldo Cruz, Salvador

[9] Instituto de Ciências da Saúde, Universidade Federal da Bahia, Avenida Reitor Miguel Calmon, 40110-100 Salvador, Bahia

来源：

BMC Research Notes | / 7卷 / 1期

基金：

英国惠康基金;

关键词：

Asthma; Atopy; Cytokines; Eosinophilia; Helminth infections; Total IgE; Treg cells;

D O I：

10.1186/1756-0500-7-817

中图分类号：

学科分类号：

摘要：

Background: Helminths are modulators of the host immune system, and infections with these parasites have been associated with protection against allergies and autoimmune diseases. The human host is often infected with multiple helminth parasites and most studies to date have investigated the effects of helminths in the context of infections with single parasite or types of parasites (e.g. geohelminths). In this study, we investigated how co-infections with three nematodes affect markers of allergic inflammation and asthma in children. We selected Ascaris lumbricoides and Trichuris trichiura, two parasites that inhabit the human intestine and Toxocara spp (Toxocara canis and/or T. cati), intestinal roundworms of dogs and cats that cause systemic larval infection in humans. These parasites were selected as the most prevalent helminth parasites in our study population. Results: 36.4% of children were infected with one parasite; 12.7% with 2 and 5.2% with 3. Eosinophilia >4% and >10% was present in 74.3% and 25.5% of the children, respectively. Total IgE > 200 IU/mL, sIgE ≥ 0.70 kU/L and SPT positivity were present in 59.7%, 37.1% and 30% of the children, respectively. 22.7% had recent asthma (12.0% non-Atopic and 10.7% atopic). Helminth infections were associated in a dose-dependent way to decrease in the prevalence of SPT and increase in eosinophilia, total IgE, and the production of the regulatory cytokine IL-10 by unstimulated peripheral blood leukocytes. No association with asthma was observed. Conclusions: Helminth co-infections in this population were associated with increased markers of the Th2 immune response, and with a host immune regulatory phenotype that may suppress allergic effector responses such as immediate hypersensitivity reactions in the skin. © 2014 Alcantara-Neves et al.

引用

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