The extent of induction of CYP3A by St. John’s wort varies among products and is linked to hyperforin dose

[1] Bjornsson TD(2003)The conduct of in vitro and in vivo drug drug interaction studies: a PhRMA perspective J Clin Pharmacol 43 443-469

[2] Callaghan JT(2002)In vitro receptor screening of pure constituents of St. John’s wort reveals novel interactions with a number of GPCRs Psychopharmacology 162 193-202

[3] Einolf HJ(2003)Mechanism of action of St. John’s wort in depression—What is known? CNS Drugs 17 539-562

[4] Fischer V(2002)Determining hyperforin and hypericin content in eight brands of St. John’s wort Am J Health Syst Pharm 59 545-547

[5] Gan L(1990)The determination of total and unbound midazolam in human plasma. A comparison of high performance liquid chromatography, gas chromatography and gas chromatography/mass spectrometry Biomed Chromatogr 4 28-33

[6] Grimm S(2002)Pharmacokinetics and metabolism of oral midazolam in preterm infants Br J Clin Pharmacol 53 390-392

[7] Kao J(2003)Analysis of the hypericin and pseudohypericin content of commercially available St. John’s wort preparations Can J Clin Pharmacol 10 114-118

[8] King SP(2003)Coordinate induction of both cytochrome P4503A and MDR1 by St. John’s wort in healthy subjects Clin Pharmacol Ther 73 41-50

[9] Miwa G(2000)St. John’s wort induces intestinal p-glycoprotein/MDR1 and intestinal and hepatic CYP3A4 Clin Pharmacol Ther 68 598-604

[10] Ni L(1997)Johanniskraut und dessen Zubereitungen Dtsch Apoth Ztg 137 3753-3757

[1] Bjornsson TD(2003)The conduct of in vitro and in vivo drug drug interaction studies: a PhRMA perspective J Clin Pharmacol 43 443-469

[2] Callaghan JT(2002)In vitro receptor screening of pure constituents of St. John’s wort reveals novel interactions with a number of GPCRs Psychopharmacology 162 193-202

[3] Einolf HJ(2003)Mechanism of action of St. John’s wort in depression—What is known? CNS Drugs 17 539-562

[4] Fischer V(2002)Determining hyperforin and hypericin content in eight brands of St. John’s wort Am J Health Syst Pharm 59 545-547

[5] Gan L(1990)The determination of total and unbound midazolam in human plasma. A comparison of high performance liquid chromatography, gas chromatography and gas chromatography/mass spectrometry Biomed Chromatogr 4 28-33

[6] Grimm S(2002)Pharmacokinetics and metabolism of oral midazolam in preterm infants Br J Clin Pharmacol 53 390-392

[7] Kao J(2003)Analysis of the hypericin and pseudohypericin content of commercially available St. John’s wort preparations Can J Clin Pharmacol 10 114-118

[8] King SP(2003)Coordinate induction of both cytochrome P4503A and MDR1 by St. John’s wort in healthy subjects Clin Pharmacol Ther 73 41-50

[9] Miwa G(2000)St. John’s wort induces intestinal p-glycoprotein/MDR1 and intestinal and hepatic CYP3A4 Clin Pharmacol Ther 68 598-604

[10] Ni L(1997)Johanniskraut und dessen Zubereitungen Dtsch Apoth Ztg 137 3753-3757