Scope and limitations of optical pure hydantoins as chiral auxiliaries in asymmetric Mannich reactions

被引：0
作者：
Feng Chen
Cuifen Lu
Junqi Nie
Zuxing Chen
Guichun Yang
机构：
[1] Hubei University,Hubei Collaborative Innovation Center for Advanced Organochemical Materials & Ministry of Education Key Laboratory for the Synthesis and Application of Organic Functional Molecules
来源：
Chemical Research in Chinese Universities | 2016年 / 32卷
关键词：
Scope; Limitation; Hydantoin; Chiral auxiliary; Mannich reaction;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
The Mannich reaction of various 5-substituted and N-acyl substituted chiral hydantoins with a series of aldimines smoothly occurred with full stereochemical control. These Mannich adducts have been cleaved by alcoholysis to afford several synthetically useful chiral building blocks like β-amino esters and β-lactams in good yields and in enantiopure form.
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页码：219 / 225
页数：6
相关论文
共 72 条
[1]  
Akiyama T.(2014)undefined Comprehensive Orgranic Synthesis(2nd Ed.) 2 629-undefined
[2]  
Xiao H.(2014)undefined Molecules 19 3955-undefined
[3]  
Wu F.(2012)undefined Comprehensive Chirality 4 293-undefined
[4]  
Shi L.(2012)undefined Top. Curr. Chem. 311 69-undefined
[5]  
Chen Z. W.(2011)undefined Eur. J. Org. Chem. 2011 4743-undefined
[6]  
Su S. H.(2012)undefined Chinese J. Chem. 30 2333-undefined
[7]  
Tang C. H.(2010)undefined Org. Lett. 12 708-undefined
[8]  
Wang H. T.(2009)undefined Chinese Chem. Lett. 20 407-undefined
[9]  
Li Z. N.(2015)undefined J. Am. Chem. Soc. 137 1040-undefined
[10]  
Li M. C.(2013)undefined Chem. Asian J. 2 208-undefined
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