Rim enhancement of breast cancers on contrast-enhanced MR imaging: relationship with prognostic factors.

被引：37
作者：
Jinguji M. [1 ]
Kajiya Y. [1 ]
Kamimura K. [1 ]
Nakajo M. [1 ]
Sagara Y. [1 ]
Takahama T. [1 ]
Ando M. [1 ]
Rai Y. [1 ]
Sagara Y. [1 ]
Ohi Y. [1 ]
Yoshida H. [1 ]
机构：
[1] Department of Radiology, Kagoshima University Graduate School of Medical and Dental Sciences, Kagoshima
来源：
Breast Cancer | 2006年 / 13卷 / 1期
关键词：
Breast cancer; MRI; Rim enhancement; Prognostic factor;
D O I：
10.2325/jbcs.13.64
中图分类号：
学科分类号：
摘要：
BACKGROUND: There is little evidence regarding associations between magnetic resonance imaging (MRI) features and other important histopathological prognostic factors of breast cancer. The purpose of our study was to investigate the relationship between rim enhancement on MRI and common histopathological prognostic factors of breast cancers. METHODS: We reviewed the contrast-enhanced MR images of 106 consecutive women with histopathologically verified invasive breast carcinomas. Three radiologists assessed the images of each lesion for the presence of rim enhancement on early and delayed images, which were classified into four patterns. Statistical analyses were performed to explore the associations of these patterns with common histopathological prognostic factors and patient age. RESULTS: Positive ratios of lymph node metastasis and blood vessel invasion and negative ratios of hormone receptors were higher in the invasive cancers with rim enhancement than those without rim enhancement. Rim enhancement was more frequent in invasive ductal cancers with a higher histological grade and larger invasive cancers. The pattern of rim enhancement with centripetal progression showed a significantly increased risk of lymph node metastasis and was associated with a larger size of invasive lesion when compared with the other patterns. Invasive cancers with rim enhancement and little change between the early and delayed images and with centrifugal progression showed significantly less hormone receptor positivity than those without rim enhancement. CONCLUSIONS: Rim enhancement patterns of breast cancers on contrast-enhanced MRI are related to common histopathological prognostic factors and these patterns may be valuable in the preoperative evaluation of breast cancers.
引用
收藏
页码：64 / 73
页数：9
相关论文
共 150 条
  • [1] Harms SE(1993)MR imaging of the breast with rotating delivery of excitation off resonance: clinical experience with pathologic correlation Radiology 187 493-501
  • [2] Flamig DP(1995)Suspect breast lesions: findings at dynamic gadolinium-enhanced MR imaging correlated with mammographic and pathologic features Radiology 197 387-395
  • [3] Hesley KL(1995)Breast tumors: comparative accuracy of MR imaging relative to mammography and US for demonstrating extent Radiology 197 743-747
  • [4] Meiches MD(2001)MR imaging of the breast for the detection, diagnosis, and staging of breast cancer Radiology 220 13-30
  • [5] Jensen RA(1991)MR imaging of the breast with Gd-DTPA enhancement: comparison with mammography and ultrasonography Radiation Medicine 9 232-240
  • [6] Evans WP(1997)Patterns of peripheral enhancement in breast masses: correlation of findings on contrast medium enhanced MRI with histologic features and tumor angiogenesis J Comput Assist Tomogr 21 421-430
  • [7] Savino DA(1998)Peripheral enhancement and spatial contrast uptake heterogeneity of primary breast tumours: quantitative assessment with dynamic MRI J Comput Assist Tomogr 22 35-46
  • [8] Wells RV(1991)Pathological prognostic factors in breast cancer. I. The value of histological grade in breast cancer: experience from a large study with long-term follow-up Histopathology 19 403-410
  • [9] Stamper PC(1999)Pathological prognostic factors in breast cancer Crit Rev Oncol Hematol 31 209-223
  • [10] Herman S(1996)Invasive breast carcinoma: analysis of dynamic magnetic resonance imaging enhancement features and cell proliferative activity determined by DNA S-phase percentage Cancer 77 1844-1849
12345678910