Rationale and methods of a randomized controlled trial of immunogenicity, safety and impact on carriage of pneumococcal conjugate and polysaccharide vaccines in infants in Papua New Guinea

Liu L(2016)Global, regional, and national causes of under-5 mortality in 2000-15: an updated systematic analysis with implications for the sustainable development goals Lancet 388 3027-3035

Oza S(2016)Causes of death collaborators. Global, regional, and national life expectancy, all-cause mortality, and cause-specific mortality for 249 causes of death, 1980-2015: a systematic analysis for the global burden of disease study 2015 Lancet 388 1459-1544

Hogan D(2013)Safety and immunogenicity of neonatal pneumococcal conjugate vaccination in Papua new Guinean children: a randomised controlled trial PLoS One 8 e56698-e209

Chu Y(2010)Burden of invasive pneumococcal disease and serotype distribution among Streptococcus Pneumoniae isolates in young children in Europe: impact of the 7-valent pneumococcal conjugate vaccine and considerations for future conjugate vaccines Int J Infect Dis 14 e197-1638

Perin J(2009)Maternal antibodies to pneumolysin but not to pneumococcal surface protein a delay early pneumococcal carriage in high-risk Papua new Guinean infants Clin Vaccine Immunol 16 1633-43

Zhu J(2016)Limited impact of neonatal or early infant schedules of 7-valent pneumococcal conjugate vaccination on nasopharyngeal carriage of Vaccine Rep 6 36-604

Mortality GBD(2004) in Papua new Guinean children: a randomized controlled trial Expert Rev Vaccines 3 597-325

Pomat WS(2014)Pneumococcal vaccine development J Inf Secur 69 309-11

Van den Biggelaar AHJ(2002)Review: current and new generation pneumococcal vaccines Clin Exp Immunol 130 4-6847

Phuanukoonnon S(2011)The dual function of the splenic marginal zone: essential for initiation of anti-TI-2 responses but also vital in the general first-line defense against blood-borne antigens Vaccine 29 6838-2196

Liu L(2016)Global, regional, and national causes of under-5 mortality in 2000-15: an updated systematic analysis with implications for the sustainable development goals Lancet 388 3027-3035

Oza S(2016)Causes of death collaborators. Global, regional, and national life expectancy, all-cause mortality, and cause-specific mortality for 249 causes of death, 1980-2015: a systematic analysis for the global burden of disease study 2015 Lancet 388 1459-1544

Hogan D(2013)Safety and immunogenicity of neonatal pneumococcal conjugate vaccination in Papua new Guinean children: a randomised controlled trial PLoS One 8 e56698-e209

Chu Y(2010)Burden of invasive pneumococcal disease and serotype distribution among Streptococcus Pneumoniae isolates in young children in Europe: impact of the 7-valent pneumococcal conjugate vaccine and considerations for future conjugate vaccines Int J Infect Dis 14 e197-1638

Perin J(2009)Maternal antibodies to pneumolysin but not to pneumococcal surface protein a delay early pneumococcal carriage in high-risk Papua new Guinean infants Clin Vaccine Immunol 16 1633-43

Zhu J(2016)Limited impact of neonatal or early infant schedules of 7-valent pneumococcal conjugate vaccination on nasopharyngeal carriage of Vaccine Rep 6 36-604

Mortality GBD(2004) in Papua new Guinean children: a randomized controlled trial Expert Rev Vaccines 3 597-325

Pomat WS(2014)Pneumococcal vaccine development J Inf Secur 69 309-11

Van den Biggelaar AHJ(2002)Review: current and new generation pneumococcal vaccines Clin Exp Immunol 130 4-6847

Phuanukoonnon S(2011)The dual function of the splenic marginal zone: essential for initiation of anti-TI-2 responses but also vital in the general first-line defense against blood-borne antigens Vaccine 29 6838-2196