Polymorphisms in the gene encoding the voltage-dependent Ca2+ channel CaV2.3 (CACNA1E) are associated with type 2 diabetes and impaired insulin secretion

被引：0
作者：
J. Holmkvist
D. Tojjar
P. Almgren
V. Lyssenko
C. M. Lindgren
B. Isomaa
T. Tuomi
G. Berglund
E. Renström
L. Groop
机构：
[1] Lund University,Department of Clinical Sciences—Diabetes and Endocrinology, CRC, Malmö University Hospital MAS
[2] Oxford University,Wellcome Trust Centre for Human Genetics and Oxford Centre for Diabetes, Endocrinology and Metabolism (OCDEM)
[3] Clinical Research Centre,Department of Medicine, Helsinki University Central Hospital and Research Program of Molecular Medicine
[4] Karolinska Institute,Department of Medicine, Malmö University Hospital
[5] Malmska Municipal Health Care Center and Hospital,undefined
[6] Folkhälsan Research Centre,undefined
[7] University of Helsinki,undefined
[8] Lund University,undefined
来源：
Diabetologia | 2007年 / 50卷
关键词：
Association; Insulin; Insulin secretion; Single nucleotide polymorphism; SNP; Voltage-dependent Ca; channel Ca; 2.3;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
引用
收藏
页码：2467 / 2475
页数：8
相关论文
共 126 条
[1]  
Alberti KG(1998)Definition, diagnosis and classification of diabetes mellitus and its complications. Part 1: diagnosis and classification of diabetes mellitus provisional report of a WHO consultation Diabet Med 15 539-553
[2]  
Zimmet PZ(2003)Large-scale association studies of variants in genes encoding the pancreatic beta-cell KATP channel subunits Kir6.2 (KCNJ11) and SUR1 (ABCC8) confirm that the KCNJ11 E23K variant is associated with type 2 diabetes Diabetes 52 568-572
[3]  
Gloyn AL(2006)Variant of transcription factor 7-like 2 (TCF7L2) gene confers risk of type 2 diabetes Nat Genet 38 320-323
[4]  
Weedon MN(2006)Common variants in HNF-1a and risk of type 2 diabetes Diabetologia 49 2882-2891
[5]  
Owen KR(2004)Genetic variation near the hepatocyte nuclear factor-4{alpha} gene predicts susceptibility to type 2 diabetes Diabetes 53 1141-1149
[6]  
Grant SFA(2004)A common polymorphism in the upstream promoter region of the hepatocyte nuclear factor-4{alpha} gene on chromosome 20q is associated with type 2 diabetes and appears to contribute to the evidence for linkage in an Ashkenazi Jewish population Diabetes 53 1134-1140
[7]  
Thorleifsson G(2007)A genome-wide association study identifies novel risk loci for type 2 diabetes Nature 445 881-885
[8]  
Reynisdottir I(2007)Replication of genome-wide association signals in UK samples reveals risk loci for type 2 diabetes Science (New York, NY) 316 1336-1341
[9]  
Holmkvist J(2007)Genome-wide association analysis identifies loci for type 2 diabetes and triglyceride levels Science 316 1331-1336
[10]  
Cervin C(2007)A variant in CDKAL1 influences insulin response and risk of type 2 diabetes Nat Genet 39 770-775
12345678910