Roles of the crotonyl-CoA carboxylase/reductase homologues in acetate assimilation and biosynthesis of immunosuppressant FK506 in Streptomyces tsukubaensis

[1] Kornberg HL(1958)The metabolism of C2 compounds in microorganisms. 3. Synthesis of malate from acetate via the glyoxylate cycle Biochem J 68 549-557

[2] Madsen NB(2007)Synthesis of C5-dicarboxylic acids from C2-units involving crotonyl-CoA carboxylase/reductase: the ethylmalonyl-CoA pathway Proc Natl Acad Sci USA 104 10631-10636

[3] Erb TJ(2014)Characterization and engineering of the ethylmalonyl-CoA pathway towards the improved heterologous production of polyketides in Appl Microbiol Biotechnol. 98 3701-13

[4] Berg IA(2012)Unusual carbon fixation gives rise to diverse polyketide extender units Nat Chem Biol 8 117-124

[5] Brecht V(2010)Origin of the allyl group in FK506 biosynthesis J Biol Chem 285 14292-14300

[6] Muller M(2012)Improvement of FK506 production in Appl Environ Microbiol 78 5093-5103

[7] Fuchs G(2012) by genetic enhancement of the supply of unusual polyketide extender units via utilization of two distinct site-specific recombination systems Enzyme Microb Technol 51 388-395

[8] Alber BE(2011)Enhancement of tacrolimus productivity in J Am Chem Soc 133 976-985

[9] Jung WS(2008) by the use of novel precursors for biosynthesis Org Biomol Chem 6 500-506

[10] Kim E(2012)Biosynthesis of the allylmalonyl-CoA extender unit for the FK506 polyketide synthase proceeds through a dedicated polyketide synthase and facilitates the mutasynthesis of analogues Metab Eng 14 39-46

[1] Kornberg HL(1958)The metabolism of C2 compounds in microorganisms. 3. Synthesis of malate from acetate via the glyoxylate cycle Biochem J 68 549-557

[2] Madsen NB(2007)Synthesis of C5-dicarboxylic acids from C2-units involving crotonyl-CoA carboxylase/reductase: the ethylmalonyl-CoA pathway Proc Natl Acad Sci USA 104 10631-10636

[3] Erb TJ(2014)Characterization and engineering of the ethylmalonyl-CoA pathway towards the improved heterologous production of polyketides in Appl Microbiol Biotechnol. 98 3701-13

[4] Berg IA(2012)Unusual carbon fixation gives rise to diverse polyketide extender units Nat Chem Biol 8 117-124

[5] Brecht V(2010)Origin of the allyl group in FK506 biosynthesis J Biol Chem 285 14292-14300

[6] Muller M(2012)Improvement of FK506 production in Appl Environ Microbiol 78 5093-5103

[7] Fuchs G(2012) by genetic enhancement of the supply of unusual polyketide extender units via utilization of two distinct site-specific recombination systems Enzyme Microb Technol 51 388-395

[8] Alber BE(2011)Enhancement of tacrolimus productivity in J Am Chem Soc 133 976-985

[9] Jung WS(2008) by the use of novel precursors for biosynthesis Org Biomol Chem 6 500-506

[10] Kim E(2012)Biosynthesis of the allylmalonyl-CoA extender unit for the FK506 polyketide synthase proceeds through a dedicated polyketide synthase and facilitates the mutasynthesis of analogues Metab Eng 14 39-46