SRS2 and SGS1 prevent chromosomal breaks and stabilize triplet repeats by restraining recombination

被引：0
作者：
Alix Kerrest
Ranjith P Anand
Rangapriya Sundararajan
Rodrigo Bermejo
Giordano Liberi
Bernard Dujon
Catherine H Freudenreich
Guy-Franck Richard
机构：
[1] Institut Pasteur,Department of Biology
[2] Unité de Génétique Moléculaire des Levures,undefined
[3] CNRS,undefined
[4] URA2171,undefined
[5] Université Pierre et Marie Curie,undefined
[6] UFR 927,undefined
[7] Tufts University,undefined
[8] Instituto FIRC di Oncologia Molecolare,undefined
[9] Via Amadello 16,undefined
来源：
Nature Structural & Molecular Biology | 2009年 / 16卷
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摘要：
Triple expansions underlie a number of human disorders. Triplet repeat instability in yeast mutants for the Srs2 and Sgs1 helicases indicate that recombination underlies instability in such a genetic background. Further analysis of replication intermediates indicates that Srs2 is likely to be involved in replication fork reversal within repetitive sequences, a process involved in preventing repeat instability and fragility.
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页码：159 / 167
页数：8
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