Profound early control of highly pathogenic SIV by an effector memory T-cell vaccine

被引：0

作者：

Scott G. Hansen

Julia C. Ford

Matthew S. Lewis

Abigail B. Ventura

Colette M. Hughes

Lia Coyne-Johnson

Nathan Whizin

Kelli Oswald

Rebecca Shoemaker

Tonya Swanson

Alfred W. Legasse

Maria J. Chiuchiolo

Christopher L. Parks

Michael K. Axthelm

Jay A. Nelson

Michael A. Jarvis

Michael Piatak

Jeffrey D. Lifson

Louis J. Picker

机构：

[1] Vaccine and Gene Therapy Institute,Departments of Molecular Microbiology and Immunology and Pathology

[2] and the Oregon National Primate Research Center,undefined

[3] Oregon Health & Science University,undefined

[4] AIDS and Cancer Virus Program,undefined

[5] SAIC Frederick Inc.,undefined

[6] National Cancer Institute-Frederick,undefined

[7] International AIDS Vaccine Initiative,undefined

[8] Vaccine Design and Development Laboratory,undefined

[9] 140 58th Street,undefined

[10] Building A,undefined

[11] Unit 8J,undefined

[12] Brooklyn,undefined

[13] New York 11220,undefined

[14] USA ,undefined

来源：

Nature | 2011年 / 473卷

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摘要：

Following some high-profile clinical trial failures in recent years, the emphasis in HIV/AIDS vaccine research has shifted away from T-cell-based vaccines that control viral replication towards vaccines that block acquisition of infection. Hansen et al. take a novel route to T-cell-based immunity, using cytomegalovirus (CMV) vectors. They find that vaccination with a rhesus-CMV-based vaccine against simian immunodeficiency virus (SIV) provides long-term protection from SIV challenge in rhesus macaques. Protection seems to be mediated by tissue-resident T-effector memory responses, suggesting that persistent vectors such as CMV may be effective in HIV/AIDS vaccines.

引用

页码：523 / 527

页数：4

共 59 条

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