Small Non-coding RNAs Govern Mammary Gland Tumorigenesis

被引：0
作者：
Zuoren Yu
Richard G. Pestell
机构：
[1] East Hospital,Research Center for Translational Medicine
[2] Tongji University School of Medicine,Department of Cancer Biology
[3] Thomas Jefferson University,Kimmel Cancer Center, Department of Cancer Biology
[4] Thomas Jefferson University,undefined
来源：
Journal of Mammary Gland Biology and Neoplasia | 2012年 / 17卷
关键词：
Non-coding RNA; miRNA; Breast cancer; Tumorigenesis; Cell cycle;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
Small non-coding RNAs include siRNA, miRNA, piRNA and snoRNA. The involvement of miRNAs in the regulation of mammary gland tumorigenesis has been widely studied while the role for other small non-coding RNAs remains unclear. Here we summarize the involvement of miRNA in breast cancer onset and progression through regulating the cell cycle and cellular proliferation. The regulation of breast cancer stem cells and tumor regeneration by miRNA is reviewed. In addition, the emerging evidence demonstrating the involvement of piRNA and snoRNA in breast cancer is briefly described.
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页码：59 / 64
页数：5
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