Toxicokinetics of ochratoxin A in vervet monkeys (Cercopithecus aethiops)

被引：0

作者：

Maria A. Stander

Thalma W. Nieuwoudt

Pieter S. Steyn

Gordon S. Shephard

Edmond E. Creppy

Vikash Sewram

机构：

[1] School for Chemistry and Biochemistry,

[2] University of Potchefstroom,undefined

[3] Potchefstroom,undefined

[4] 2520,undefined

[5] South Africa,undefined

[6] Department of Chemistry,undefined

[7] University of Stellenbosch,undefined

[8] P.O. Box X1,undefined

[9] Matieland,undefined

[10] 7602,undefined

[11] South Africa,undefined

[12] Programme on Mycotoxins and Experimental Carcinogenesis (PROMEC),undefined

[13] Medical Research Council,undefined

[14] P.O. Box 19070,undefined

[15] Tygerberg,undefined

[16] 7505,undefined

[17] South Africa,undefined

[18] Laboratoire de Toxicologie et d'Hygiène Appliquée,undefined

[19] Université Victor Segalen Bordeaux 2,undefined

[20] 146 rue Léo-Saignat,undefined

[21] 33076 Bordeaux cedex,undefined

[22] France,undefined

来源：

Archives of Toxicology | 2001年 / 75卷

关键词：

Ochratoxin A Toxicokinetics Cercopithecus aethiops Intravenous Negative ion electrospray ionization mass spectrometry;

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摘要：

The toxicokinetics of ochratoxin A were investigated in vervet monkeys (Cercopithecus aethiops). Three female monkeys were treated intravenously with ochratoxin A at doses, respectively, of 0.8, 1.5 and 2 mg/kg body weight (BW). Blood and urine samples were collected over a period of 21 days. Plasma and urine extracts were analysed by high-performance liquid chromatography (HPLC) with either fluorescence or negative ion electrospray ionization mass spectrometric detection. The clearance of ochratoxin A from plasma followed a two-compartment model. The elimination half-life of ochratoxin A in the monkeys was determined to be 19–21 days and the average total body clearance was 0.22±0.07 ml/h per kg and the average apparent distribution volume of the central compartment was 59±9 ml/kg and the peripheral compartment was 59±20 ml/kg. No evidence was found for any metabolic conversion of ochratoxin A.

引用

页码：262 / 269

页数：7