A Two-Year Longitudinal MRI Study of the Corpus Callosum in Autism

被引：0
作者：
Thomas W. Frazier
Matcheri S. Keshavan
Nancy J. Minshew
Antonio Y. Hardan
机构：
[1] Cleveland Clinic,Center for Autism (CRS10) and Pediatric Behavioral Health
[2] Harvard Medical School,Department of Psychiatry, Beth Israel and Deaconess Medical Center
[3] University of Pittsburgh School of Medicine,Western Psychiatric Institute and Clinic
[4] Stanford University,Department of Psychiatry and Behavioral Sciences
来源：
Journal of Autism and Developmental Disorders | 2012年 / 42卷
关键词：
Magnetic resonance imaging; Autism; Corpus callosum; Rostral body;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
A growing body of literature has identified size reductions of the corpus callosum (CC) in autism. However, to our knowledge, no published studies have reported on the growth of CC volumes in youth with autism. Volumes of the total CC and its sub-divisions were obtained from 23 male children with autism and 23 age- and gender-matched controls at baseline and 2-year follow-up. Persistent reductions in total CC volume were observed in participants with autism relative to controls. Only the rostral body subdivision showed a normalization of size over time. Persistent reductions are consistent with the diagnostic stability and life-long impairment observed in many individuals with autism. Multi-modal imaging studies are needed to identify specific fiber tracks contributing to CC reductions.
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页码：2312 / 2322
页数：10
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