pH dependent hydrolysis and drug release behavior of chitosan/poly(ethylene glycol) polymer network microspheres

被引：0
作者：
K. C. Gupta
Majeti N. V. Ravi Kumar
机构：
[1] University of Roorkee,Polymer Research Laboratory, Department of Chemistry
来源：
Journal of Materials Science: Materials in Medicine | 2001年 / 12卷
关键词：
Chitosan; Drug Release; Isoniazid; Control Release; Crosslinking Agent;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
Semi-interpenetrating polymer network (IPN) microspheres of chitosan and poly(ethylene glycol) PEG were prepared for controlled release of drugs. A new method for the chemical crosslinking of chitosan microspheres containing isoniazid (INH) as a model drug is proposed and evaluated. The method consists of the exposure of microspheres to the vapor of crosslinking agent that act in gaseous phase under mild conditions. The structural analysis of the microspheres was carried out by FTIR-analysis. The swelling behavior, hydrolytic degradation, structural changes of the microspheres and loading capacity (LC) of the microspheres for INH were investigated. The prepared microspheres have shown 93% drug loading capacity, which suggested that these semi-IPN microspheres are suitable for controlled release of drugs in an oral sustained delivery system. © 2001 Kluwer Academic Publishers
引用
收藏
页码：753 / 759
页数：6
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