Significance of serrated polyps of the colon

被引：41
作者：
Groff R.J. [1 ]
Nash R. [1 ]
Ahnen D.J. [1 ]
机构：
[1] University of Colorado Denver School of Medicine, Denver, CO 80220
来源：
Current Gastroenterology Reports | 2008年 / 10卷 / 5期
关键词：
Adenoma; Lynch Syndrome; BRAF Mutation; Hyperplastic Polyp; Serrate Polyp;
D O I：
10.1007/s11894-008-0090-z
中图分类号：
学科分类号：
摘要：
The fundamental view that colon adenocarcinomas arise only from conventional adenomas has been challenged by the now recognized hyperplastic polyp-serrated adenoma-adenocarcinoma pathway. This article describes the history of the serrated adenoma (both the traditional serrated adenoma and the sessile serrated adenoma) as well as the histology and endoscopic appearance of these lesions in comparison with hyperplastic polyps and mixed polyps. Although the exact pathway is the subject of ongoing research, compelling histologic associations and molecular phenotypes that define the model of the serrated polyp-carcinoma sequence, including microsatellite instability, BRAF/KRAS mutations, and CpG island methylator phenotype, provide strong evidence that this is a genuine pathway. Management of serrated neoplasia of the colon includes careful colonoscopy, complete removal of colonic polyps, sampling fields of diminutive polyps of the rectosigmoid, and basing surveillance on histology of removed polyps. © Springer Science+Business Media, LLC 2008.
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收藏
页码：490 / 498
页数：8
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