Thrombosis in vasculitis: From pathogenesis to treatment

被引：107

作者：

Emmi G. ^{[1
]}

Silvestri E. ^{[1
]}

Squatrito D. ^{[1
]}

Amedei A. ^{[1
,2
]}

Niccolai E. ^{[1
]}

D'Elios M.M. ^{[1
,2
]}

Della Bella C. ^{[1
]}

Grassi A. ^{[1
]}

Becatti M. ^{[3
]}

Fiorillo C. ^{[3
]}

Emmi L. ^{[2
]}

Vaglio A. ^{[4
]}

Prisco D. ^{[1
,2
]}

机构：

[1] University of Florence, Department of Experimental and Clinical Medicine, L.go G. Brambilla, Florence, 3

[2] SOD Interdisciplinary Internal Medicine, Center for Autoimmune Systemic Diseases-Behçet Center, Lupus Clinic-AOU Careggi Hospital of Florence, Florence

[3] University of Florence, Department of Experimental and Clinical Biomedical Sciences, Florence

[4] University Hospital of Parma, Nephrology Unit, Parma

来源：

Thrombosis Journal | / 13卷 / 1期

关键词：

ANCA associated vasculitis; Behçet syndrome; Deep vein thrombosis; Inflammation-induced thrombosis; Large vessel vasculitis; Thrombo-embolic disease;

D O I：

10.1186/s12959-015-0047-z

中图分类号：

学科分类号：

摘要：

In recent years, the relationship between inflammation and thrombosis has been deeply investigated and it is now clear that immune and coagulation systems are functionally interconnected. Inflammation-induced thrombosis is by now considered a feature not only of autoimmune rheumatic diseases, but also of systemic vasculitides such as Behçet's syndrome, ANCA-associated vasculitis or giant cells arteritis, especially during active disease. These findings have important consequences in terms of management and treatment. Indeed, Behçet'syndrome requires immunosuppressive agents for vascular involvement rather than anticoagulation or antiplatelet therapy, and it is conceivable that also in ANCA-associated vasculitis or large vessel-vasculitis an aggressive anti-inflammatory treatment during active disease could reduce the risk of thrombotic events in early stages. In this review we discuss thrombosis in vasculitides, especially in Behçet's syndrome, ANCA-associated vasculitis and large-vessel vasculitis, and provide pathogenetic and clinical clues for the different specialists involved in the care of these patients. © Emmi et al.

引用

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