Protective effect of water extract of guibi-tang against pulmonary inflammation induced by cigarette smoke and lipopolysaccharide

被引：4

作者：

Shin N.-R. ^{[1
]}

Jung T.-Y. ^{[1
]}

Seo C.-S. ^{[2
]}

Park S.-W. ^{[1
]}

Ko J.-W. ^{[1
]}

Kim J.-C. ^{[1
]}

Shin I.-S. ^{[1
]}

机构：

[1] College of Veterinary Medicine (BK21 Plus Project Team), Chonnam National University, 77 Yongbong-ro, Buk-gu, Gwangju

[2] K-herb Research Center, Korea Institute of Oriental Medicine, Daejeon

来源：

Laboratory Animal Research | 2018年 / 34卷 / 3期

关键词：

airway inflammation; cigarette smoke; Guibi-water extract; inducible nitric oxide synthase;

D O I：

10.5625/lar.2018.34.3.92

中图分类号：

学科分类号：

摘要：

Water extract of guibi-tang (GB), a traditional Chinese, Japanese, and Korean herbal medicine, is used to treat memory impairment, insomnia, and peptic ulcers. The aim of this study was to investigate the protective effects of GB on pulmonary inflammation induced by cigarette smoke (CS) and lipopolysaccharide (LPS). C57BL/6 mice were used to develop a pulmonary inflammation model by exposing them to CS for 1 h per day for 7 days. LPS was intranasally administered to mice under mild anesthesia on day 5. GB was administered 1 h before CS exposure at doses of 50 or 100 mg/kg for 7 days. Our results showed that GB suppressed the CS and LPS induced elevation in inflammatory cell counts in the bronchoalveolar lavage fluid (BALF), with significant reductions in protein, tumor necrosis factor (TNF)-α, and interleukin (IL)-6 levels. Histological studies revealed that GB decreased the inflammatory cell infiltration into lung tissue caused by CS- and LPS-exposure. GB also significantly decreased the CS and LPS-induced expression of inducible nitric oxide synthase (iNOS) in the lung tissue. Taken together, GB effectively attenuated airway inflammation caused by CS and LPS. These results indicate that GB is a potential therapeutic herbal formula for pulmonary inflammatory disease. © 2018, The Author(s).

引用

页码：92 / 100

页数：8

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