Glioblastoma stem cells and Wnt signaling pathway: Molecular mechanisms and therapeutic targets

被引：29
作者：
Guan R. [1 ]
Zhang X. [2 ]
Guo M. [1 ]
机构：
[1] Department of Neurosurgery, Second Affiliated Hospital, Harbin Medical University, 246 Xuefu Road, Nangang, Harbin, Heilongjiang Province
[2] Department of Neurology, Second Affiliated Hospital, Harbin Medical University, Harbin, Heilongjiang Province
来源：
Chinese Neurosurgical Journal | / 6卷 / 1期
基金：
中国国家自然科学基金;
关键词：
D O I：
10.1186/s41016-020-00207-z
中图分类号：
学科分类号：
摘要：
Glioblastoma is the most common form of primary brain tumor. Glioblastoma stem cells play an important role in tumor formation by activation of several signaling pathways. Wnt signaling pathway is one such important pathway which helps cellular differentiation to promote tumor formation in the brain. Glioblastoma remains to be a highly destructive type of tumor despite availability of treatment strategies like surgery, chemotherapy, and radiation. Advances in the field of cancer biology have revolutionized therapy by allowing targeting of tumor-specific molecular deregulation. In this review, we discuss about the significance of glioblastoma stem cells in cancer progression through Wnt signaling pathway and highlight the clinical targets being potentially considered for therapy in glioblastoma. © 2020 The Author(s).
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