The expression of efflux and uptake transporters are regulated by statins in Caco-2 and HepG2 cells

被引:0
|
作者
Alice Cristina Rodrigues
Rui Curi
Fabiana Dalla Vecchia Genvigir
Mario Hiroyuki Hirata
Rosario Dominguez Crespo Hirata
机构
[1] Faculty of Pharmaceutical Sciences,Department of Clinical and Toxicological Analysis
[2] University of Sao Paulo,Department of Physiology and Biophysics
[3] Institute of Biomedical Sciences,undefined
[4] University of Sao Paulo,undefined
来源
Acta Pharmacologica Sinica | 2009年 / 30卷
关键词
simvastatin; atorvastatin; Caco-2 cells; HepG2 cells; drug transporters;
D O I
暂无
中图分类号
学科分类号
摘要
引用
收藏
页码:956 / 964
页数:8
相关论文
共 47 条
  • [1] The expression of efflux and uptake transporters are regulated by statins in Caco-2 and HepG2 cells
    Rodrigues, Alice Cristina
    Curi, Rui
    Vecchia Genvigir, Fabiana Dalla
    Hirata, Mario Hiroyuki
    Crespo Hirata, Rosario Dominguez
    ACTA PHARMACOLOGICA SINICA, 2009, 30 (07) : 956 - 964
  • [2] Caco-2 cells - expression, regulation and function of drug transporters compared with human jejunal tissue
    Bruck, S.
    Strohmeier, J.
    Busch, D.
    Drozdzik, M.
    Oswald, S.
    BIOPHARMACEUTICS & DRUG DISPOSITION, 2017, 38 (02) : 115 - 126
  • [3] Simvastatin downregulates the expression of hepcidin and erythropoietin in HepG2 cells
    Chang, Chia-Chu
    Chiu, Ping-Fang
    Chen, Hung-Lin
    Chang, Tzu-Lan
    Chang, Yu-Jun
    Huang, Ching-Hui
    HEMODIALYSIS INTERNATIONAL, 2013, 17 (01) : 116 - 121
  • [4] Down-regulation of RhoA is involved in the cytotoxic action of lipophilic statins in HepG2 cells
    Maeda, Asuka
    Yano, Takahisa
    Itoh, Yoshinori
    Kakumori, Midori
    Kubota, Toshio
    Egashira, Nobuaki
    Oishi, Ryozo
    ATHEROSCLEROSIS, 2010, 208 (01) : 112 - 118
  • [5] Effects of statins on the secretion of human serum albumin in cultured HepG2 cells
    Chung-Eun Ha
    Ji-Sook Ha
    Andre G Theriault
    Nadhipuram V Bhagavan
    Journal of Biomedical Science, 16
  • [6] Effects of statins on the secretion of human serum albumin in cultured HepG2 cells
    Ha, Chung-Eun
    Ha, Ji-Sook
    Theriault, Andre G.
    Bhagavan, Nadhipuram V.
    JOURNAL OF BIOMEDICAL SCIENCE, 2009, 16
  • [7] Rebaudioside A Enhances LDL Cholesterol Uptake in HepG2 Cells via Suppression of HMGCR Expression
    Ilias, Amirul Nazhan
    Ismail, Intan Safmar
    Hamzah, Hazilawati
    Mohidin, Taznim Begam Mohd
    Idris, Mohd Faiz
    Ajat, Mokrish
    REPORTS OF BIOCHEMISTRY AND MOLECULAR BIOLOGY, 2021, 10 (03): : 477 - 487
  • [8] Intestinal absorptive transport of the hydrophilic cation ranitidine:: A kinetic modeling approach to elucidate the role of uptake and efflux transporters and paracellular vs. transcellular transport in caco-2 cells
    Bourdet, David L.
    Pollack, Gary M.
    Thakker, Dhiren R.
    PHARMACEUTICAL RESEARCH, 2006, 23 (06) : 1178 - 1187
  • [9] Intestinal Absorptive Transport of the Hydrophilic Cation Ranitidine: A Kinetic Modeling Approach to Elucidate the Role of Uptake and Efflux Transporters and Paracellular vs. Transcellular Transport in Caco-2 Cells
    David L. Bourdet
    Gary M. Pollack
    Dhiren R. Thakker
    Pharmaceutical Research, 2006, 23 : 1178 - 1187
  • [10] Use of Transporter Knockdown Caco-2 Cells to Investigate the In Vitro Efflux of Statin Drugs
    Li, Jibin
    Volpe, Donna A.
    Wang, Ying
    Zhang, Wei
    Bode, Chris
    Owen, Albert
    Hidalgo, Ismael J.
    DRUG METABOLISM AND DISPOSITION, 2011, 39 (07) : 1196 - 1202