Bone and the Innate Immune System

被引:0
|
作者
Julia F. Charles
Mary C. Nakamura
机构
[1] Department of Medicine,Department of Medicine, Division of Rheumatology
[2] Division of Rheumatology,undefined
[3] Allergy and Immunology,undefined
[4] Brigham and Women’s Hospital and Harvard Medical School,undefined
[5] University of California,undefined
[6] Arthritis/Immunology Section,undefined
[7] Veterans Affairs Medical Center,undefined
来源
Current Osteoporosis Reports | 2014年 / 12卷
关键词
Bone; Innate immunity; Osteoclast; Osteomac; Osteocyte; Apoptosis; Autophagy; Necroptosis;
D O I
暂无
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学科分类号
摘要
The immune system and bone are intimately linked with significant physical and functionally related interactions. The innate immune system functions as an immediate response system to initiate protections against local challenges such as pathogens and cellular damage. Bone is a very specific microenvironment, in which infectious attack is less common but repair and regeneration are ongoing and important functions. Thus, in the bone the primary goal of innate immune and bone interactions is to maintain tissue integrity. Innate immune signals are critical for removal of damaged and apoptotic cells and to stimulate normal tissue repair and regeneration. In this review we focus on the innate immune mechanisms that function to regulate bone homeostasis.
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页码:1 / 8
页数:7
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