The immune system and bone are intimately linked with significant physical and functionally related interactions. The innate immune system functions as an immediate response system to initiate protections against local challenges such as pathogens and cellular damage. Bone is a very specific microenvironment, in which infectious attack is less common but repair and regeneration are ongoing and important functions. Thus, in the bone the primary goal of innate immune and bone interactions is to maintain tissue integrity. Innate immune signals are critical for removal of damaged and apoptotic cells and to stimulate normal tissue repair and regeneration. In this review we focus on the innate immune mechanisms that function to regulate bone homeostasis.
机构:
Univ Calif San Diego, Dept Med, Div Endocrinol & Metab, La Jolla, CA 92093 USAUniv Calif San Diego, Dept Med, Div Endocrinol & Metab, La Jolla, CA 92093 USA
Lackey, Denise E.
Olefsky, Jerrold M.
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机构:
Univ Calif San Diego, Dept Med, Div Endocrinol & Metab, La Jolla, CA 92093 USAUniv Calif San Diego, Dept Med, Div Endocrinol & Metab, La Jolla, CA 92093 USA
机构:
Univ Calif Los Angeles, Dept Microbiol Immunol & Mol Genet, Los Angeles, CA 90095 USAUniv Calif Los Angeles, Dept Microbiol Immunol & Mol Genet, Los Angeles, CA 90095 USA