Addition of sodium hyaluronate and the effect on performance of the injectable calcium phosphate cement

被引:0
作者
Dan Kai
Dongxiao Li
Xiangdong Zhu
Lei Zhang
Hongsong Fan
Xingdong Zhang
机构
[1] Sichuan University,National Engineering Research Center for Biomaterials
[2] Sichuan Academy of Chinese Medicine Science,Institute of Pharmacology & Toxicology
来源
Journal of Materials Science: Materials in Medicine | 2009年 / 20卷
关键词
Compressive Strength; Hyaluronate; Simulated Body Fluid; Minimal Invasive Surgery; Calcium Phosphate Cement;
D O I
暂无
中图分类号
学科分类号
摘要
An injectable calcium phosphate cement (CPC) with porous structure and excellent anti-washout ability was developed in the study. Citric acid and sodium bicarbonate were added into the CPC powder consisting of tetracalcium phosphate (TTCP) and dicalcium phosphate dihydrate (DCPD) to form macro-pores, then different concentrations of sodium hyaluronate (NaHA) solution, as liquid phase, was added into the cement to investigate its effect on CPC’s performance. The prepared CPCs were tested on workability (injectable time and setting time), mechanical strength, as well as anti-washout ability. The experimental results showed that addition of NaHA not only enhanced the anti-washout ability of the CPC dramatically but also improve its other properties. When NaHA concentration was 0.6 wt%, the injectable time elongated to 15.7 ± 0.6 min, the initial and final setting times were respectively shorten to 18.3 ± 1.2 and 58.7 ± 2.1 min, and the compressive strength were increased to 18.78 ± 1.83 MPa. On the other hand, Addition of NaHA showed little effect on porous structure of the CPC and enhanced its bioactivity obviously, which was confirmed by the apatite formation on its surface after immersion in simulated body fluid (SBF). In conclusion, as an in situ shaped injectable biomaterials, the CPC with appropriate addition of NaHA would notably improve its performance and might be used in minimal invasive surgery for bone repair or reconstruction.
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页码:1595 / 1602
页数:7
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