Melanocytic tumours of uncertain malignant potential (MELTUMPs)—a diagnostic and management dilemma

被引:3
作者
Green R.J. [1 ,4 ]
Taghizadeh R. [1 ]
Lewis C.J. [1 ]
Lawrence C. [3 ]
Husain A. [3 ]
Ahmed O. [1 ]
机构
[1] Department of Plastic Surgery, Royal Victoria Infirmary, Queen Victoria Road, Newcastle upon Tyne
[2] Department of Dermatology, Royal Victoria Infirmary, Queen Victoria Road, Newcastle upon Tyne
[3] Department of Histopathology, Royal Victoria Infirmary, Queen Victoria Road, Newcastle upon Tyne
[4] ENT Department, Laruiston Building, Lauriston Place, Edinburgh
关键词
Melanocytic lesion of unknown malignant potential; Melanoma; MELTUMPS; MLUMPS;
D O I
10.1007/s00238-014-1028-3
中图分类号
学科分类号
摘要
Background: Melanocytic tumours of uncertain malignant potential (MELTUMPs) represent melanocytic proliferations within the dermis and are thereby associated with a potential risk of disease dissemination and metastases. However, there is a paucity of data regarding these lesions, their malignant potential and thus their management.; Methods: This is a retrospective evaluation of all MELTUMPs treated in a single tertiary plastic surgery unit to establish patient demographics, clinical management and outcomes including recurrence and regional and distant metastases.; Results: Forty-two patients were treated for MELTUMPs between 2005 and 2011 in our unit. The mean Breslow thickness was 0.85 mm (range in situ disease to 5 mm). A complete data set was available for 37 of these patients, of whom, 32 (86 %) underwent wider excision with a 1-cm margin and 5 (14 %) with 2-cm margin. The mean follow-up time was 23 months (range 2 to 48 months). One patient developed locally recurrent disease, one patient developed regional metastases and one patient died of metastatic disease.; Conclusions: MELTUMPs present a diagnostic and management dilemma with a paucity of agreed strategies for ongoing patient care. We propose that all MELTUMPs should be treated using a melanoma strategy under the care of a skin cancer multidisciplinary team.; Level of Evidence: Level IV, risk / prognostic study. © 2014, Springer-Verlag Berlin Heidelberg.
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页码:13 / 16
页数:3
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