Comprehensive bactericidal activity of an ethanol-based hand gel in 15 seconds

被引：25

作者：

Kampf G. ^{[1
,2
]}

Hollingsworth A. ^{[3
]}

机构：

[1] Bode Chemie GmbH and Co. KG, Scientific Affairs, 22525 Hamburg

[2] Institute for Hygiene and Environmental Medicine, Ernst Moritz Arndt University, 17489 Greifswald

[3] MICROBIOTEST Inc., Sterling, VA

来源：

Annals of Clinical Microbiology and Antimicrobials | / 7卷 / 1期

关键词：

Hand Hygiene; Clostridium Difficile; Acinetobacter Baumannii; Bacterial Spore; Hand Disinfection;

D O I：

10.1186/1476-0711-7-2

中图分类号：

学科分类号：

摘要：

Background: Some studies indicate that the commonly recommended 30 s application time for the post contamination treatment of hands may not be necessary as the same effect may be achieved with some formulations in a shorter application time such as 15 s. Method: We evaluated the bactericidal activity of an ethanol-based hand gel (Sterillium® Comfort Gel) within 15 s in a time-kill-test against 11 Gram-positive, 16 Gram-negative bacteria and 11 emerging bacterial pathogens. Each strain was evaluated in quadruplicate. Results: The hand gel (85% ethanol, w/w) was found to reduce all 11 Gram-positive and all 16 Gram-negative bacteria by more than 5 log10 steps within 15 s, not only against the ATCC test strains but also against corresponding clinical isolates. In addition, a log10 reduction > 5 was observed against all tested emerging bacterial pathogens. Conclusion: The ethanol-based hand gel was found to have a broad spectrum of bactericidal activity in only 15 s which includes the most common species causing nosocomial infections and the relevant emerging pathogens. Future research will hopefully help to find out if a shorter application time for the post contamination treatment of hands provides more benefits or more risks. © 2008 Kampf and Hollingsworth; licensee BioMed Central Ltd.

引用

共 36 条

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[9]

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[10]

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