The causes and consequences of genetic heterogeneity in cancer evolution

被引：0
作者：
Rebecca A. Burrell
Nicholas McGranahan
Jiri Bartek
Charles Swanton
机构：
[1] Translational Cancer Therapeutics Laboratory,
[2] Cancer Research UK London Research Institute,undefined
[3] Centre for Mathematics and Physics in the Life Sciences and Experimental Biology (CoMPLEX),undefined
[4] University College London,undefined
[5] Danish Cancer Society Research Center,undefined
[6] Institute of Molecular and Translational Medicine,undefined
[7] Palacky University,undefined
[8] UCL Cancer Institute,undefined
[9] Paul O'Gorman Building,undefined
来源：
Nature | 2013年 / 501卷
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摘要：
Recent studies have revealed extensive genetic diversity both between and within tumours. This heterogeneity affects key cancer pathways, driving phenotypic variation, and poses a significant challenge to personalized cancer medicine. A major cause of genetic heterogeneity in cancer is genomic instability. This instability leads to an increased mutation rate and can shape the evolution of the cancer genome through a plethora of mechanisms. By understanding these mechanisms we can gain insight into the common pathways of tumour evolution that could support the development of future therapeutic strategies.
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页码：338 / 345
页数：7
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