Principles of source control in the early management of sepsis

被引：38

作者：

Marshall J.C. ^{[1
]}

机构：

[1] Department of Surgery, Li Ka Shing Knowledge Institute, University of Toronto, Toronto, ON M5B 1W8

来源：

Current Infectious Disease Reports | 2010年 / 12卷 / 5期

关键词：

Cholangitis; Debridement; Device-related infection; Diverticulitis; Drainage; Empyema; Intra-abdominal infection; Necrotizing soft-tissue infection; Pancreatitis; Peritonitis; Septic shock; Severe sepsis; Source control; Surgery;

D O I：

10.1007/s11908-010-0126-z

中图分类号：

学科分类号：

摘要：

Source control refers to the spectrum of physical measures that are undertaken to control a focus of infection, and to facilitate restoration of optimal anatomy and physiology. These measures are classified as drainage-the evacuation of infected liquid through the creation of a controlled sinus or fistula, debridement-the physical removal of necrotic infected tissue, device removal, and the definitive measures that comprise the process of reconstruction and rehabilitation. Effective and timely source control is critical to the successful management of life-threatening infection. This article reviews the principles of diagnosis and source-control management, and their application to common infections that result in severe sepsis and septic shock. © 2010 Springer Science+Business Media, LLC.

引用

页码：345 / 353

页数：8

共 37 条

[1]

Source control: A guide to the management of surgical infections, Edited by Schein M, Marshall JC. Berlin: Springer, (2002)

[2]

Marshall J.C., Al Naqbi A., Principles of source control in the management of sepsis, Crit Care Clin, 25, pp. 753-768, (2009)

[3]

Schouten M., Wiersinga W.J., Levi M., Van Der Poll T., Inflammation, endothelium, and coagulation in sepsis, J Leukoc Biol, 83, pp. 536-545, (2008)

[4]

Zhang Q., Raoof M., Chen Y., Et al., Circulating mitochondrial DAMPs cause inflammatory responses to injury, Nature, 464, pp. 104-107, (2010)

[5]

Mier J., Leon E.L., Castillo A., Et al., Early versus late necrosectomy in severe necrotizing pancreatitis, Am J Surg, 173, pp. 71-75, (1997)

[6]

Donlam R.M., Biofilms on central venous catheters: Is eradication possible?, Curr Top Microbiol Immunol, 322, pp. 133-161, (2008)

[7]

Hatt J.K., Rather P.N., Role of bacterial biofilms in urinary tract infections, Curr Top Microbiol Immunol, 322, pp. 163-192, (2008)

[8]

Feldman C., Kassel M., Cantrell J., Et al., The presence and sequence of endotracheal tube colonization in patients undergoing mechanical ventilation, Eur Respir J, 13, pp. 546-551, (1999)

[9]

Stewart P.S., Costerton J.W., Antibiotic resistance of bacteria in biofilms, Lancet, 358, pp. 135-138, (2001)

[10]

Zimmerli W., Lew P.D., Waldvogel F.A., Pathogenesis of foreign body infection. Evidence for a local granulocyte defect, J Clin Invest, 73, pp. 1191-1200, (1984)

← 1 2 3 4 →