The emerging role of microRNAs in multiple sclerosis

被引：0
作者：
Andreas Junker
Reinhard Hohlfeld
Edgar Meinl
机构：
[1] University Medical Center,Department of Neuropathology
[2] Georg August University,undefined
[3] Institute of Clinical Neuroimmunology,undefined
[4] Ludwig Maximilian University of Munich,undefined
来源：
Nature Reviews Neurology | 2011年 / 7卷
关键词：
D O I：
暂无
中图分类号：
学科分类号：
摘要：
MicroRNAs (miRNAs) seem to confer a novel layer of gene regulation, possibly fine-tuning the expression of ≈50% of genes in humans. Dysfunction of these short regulatory RNAs has been noted in various neurological disorders, including Alzheimer disease and Parkinson disease. Here, Junker and colleagues explore the possible involvement of miRNAs in multiple sclerosis, highlighting the therapeutic implications for this disease.
引用
收藏
页码：56 / 59
页数：3
相关论文
共 87 条
  • [1] Eulalio A(2008)Getting to the root of miRNA-mediated gene silencing Cell 132 9-14
  • [2] Huntzinger E(2008)Let me count the ways: mechanisms of gene regulation by miRNAs and siRNAs Mol. Cell 29 1-7
  • [3] Izaurralde E(2005)Conserved seed pairing, often flanked by adenosines, indicates that thousands of human genes are microRNA targets Cell 120 15-20
  • [4] Wu L(2009)MicroRNAs in brain development and physiology Curr. Opin. Neurobiol. 19 461-470
  • [5] Belasco JG(2006)The neuronal microRNA system Nat. Rev. Neurosci. 7 911-920
  • [6] Lewis BP(2008)Identification of dynamically regulated microRNA and mRNA networks in developing oligodendrocytes J. Neurosci. 28 11720-11730
  • [7] Burge CB(2009)MicroRNA profiling of multiple sclerosis lesions identifies modulators of the regulatory protein CD47 Brain 132 3342-3352
  • [8] Bartel DP(2008)MicroRNA involvement in brain tumors: from bench to bedside Brain Pathol. 18 122-129
  • [9] Coolen M(2009)Understanding microRNAs in neurodegeneration Nat. Rev. Neurosci. 10 837-841
  • [10] Bally-Cuif L(2009)Alterations of the microRNA network cause neurodegenerative disease Trends Neurosci. 32 199-206
123456789