(Pro)renin and (pro)renin receptor expression during kidney development in neonates

被引：0
作者：
Tomomasa Terada
Maki Urushihara
Takahiko Saijo
Ryuji Nakagawa
Shoji Kagami
机构：
[1] Tokushima University Graduate School,Department of Pediatrics, Institute of Biomedical Sciences
来源：
European Journal of Pediatrics | 2017年 / 176卷
关键词：
Renin-angiotensin; Gestational age; Cord blood; Enzyme-linked immunosorbent assay; Immunohistochemistry;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
Although a recent study demonstrated that the (pro)renin receptor ((P)RR) was highly expressed in the developing kidney during the mouse embryonic development, the mechanism by which (P)RR supports renal development in humans is not fully understood. In this study, we examined the plasma levels of (pro)renin and soluble (P)RR (s(P)RR) in cord blood and neonates as well as (P)RR expression in human kidney tissues. Samples were collected from 57 preterm and 67 full-term human neonates. (Pro)renin and s(P)RR levels were measured using enzyme-linked immunosorbent assays. Additionally, we performed an immunohistochemical (IHC) analysis of kidney tissues from neonates and minor glomerular abnormalities in order to assess (P)RR expression in the kidney. Plasma (pro)renin and s(P)RR levels in cord blood were significantly higher in preterm neonates than in full-term neonates. Four weeks after birth, these differences were no longer evident for either plasma (pro)renin or s(P)RR levels between the two groups. Importantly, plasma (pro)renin and s(P)RR levels in cord blood were inversely correlated with gestational age. Furthermore, IHC indicated that renal expression levels of (P)RR in neonates were stronger than those in minor glomerular abnormalities.
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页码：183 / 189
页数：6
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