Transcriptome-based network analysis related to M2-like tumor-associated macrophage infiltration identified VARS1 as a potential target for improving melanoma immunotherapy efficacy

[1] Carlino MS(2015)Immune checkpoint inhibitors in melanoma Cell 161 1681-96

[2] Larkin J(2021)Targeting macrophages: therapeutic approaches in cancer The Lancet 398 1002-14

[3] Long GV(2018)Development of tumor mutation burden as an immunotherapy biomarker: utility for the oncology clinic Nat Rev Drug Discovery 17 887-904

[4] Cassetta L(2019)CCL18 from tumor-associated macrophages promotes breast cancer metastasis via PITPNM3 Annals of oncology: official journal of the European Society for Medical Oncology 30 44-56

[5] Pollard JW(2011)cytoHubba: identifying hub objects and sub-networks from complex interactome Cancer Cell 19 541-55

[6] Chan TA(2014)TCGAbiolinks: an R/Bioconductor package for integrative analysis of TCGA data BMC Syst Biol 8 11-1

[7] Yarchoan M(2016)GEOquery: a bridge between the Gene Expression Omnibus (GEO) and BioConductor Nucleic Acids Res 44 e71-7

[8] Jaffee E(2007)Microenvironmental regulation of tumour angiogenesis Bioinformatics 23 1846-74

[9] Swanton C(2017)HLA variation and disease Nat Rev Cancer 17 457-39

[10] Quezada SA(2018)TGFβ biology in cancer progression and immunotherapy Nat Rev Immunol 18 325-34

[1] Carlino MS(2015)Immune checkpoint inhibitors in melanoma Cell 161 1681-96

[2] Larkin J(2021)Targeting macrophages: therapeutic approaches in cancer The Lancet 398 1002-14

[3] Long GV(2018)Development of tumor mutation burden as an immunotherapy biomarker: utility for the oncology clinic Nat Rev Drug Discovery 17 887-904

[4] Cassetta L(2019)CCL18 from tumor-associated macrophages promotes breast cancer metastasis via PITPNM3 Annals of oncology: official journal of the European Society for Medical Oncology 30 44-56

[5] Pollard JW(2011)cytoHubba: identifying hub objects and sub-networks from complex interactome Cancer Cell 19 541-55

[6] Chan TA(2014)TCGAbiolinks: an R/Bioconductor package for integrative analysis of TCGA data BMC Syst Biol 8 11-1

[7] Yarchoan M(2016)GEOquery: a bridge between the Gene Expression Omnibus (GEO) and BioConductor Nucleic Acids Res 44 e71-7

[8] Jaffee E(2007)Microenvironmental regulation of tumour angiogenesis Bioinformatics 23 1846-74

[9] Swanton C(2017)HLA variation and disease Nat Rev Cancer 17 457-39

[10] Quezada SA(2018)TGFβ biology in cancer progression and immunotherapy Nat Rev Immunol 18 325-34