Are isothiocyanates potential anti-cancer drugs?

被引：0
作者：
Xiang Wu
Qing-hua Zhou
Ke Xu
机构：
[1] Tianjin Key Laboratory of Lung Cancer Metastasis and Tumor Microenviroment,
[2] Tianjin Lung Cancer Institute,undefined
[3] Tianjin Medical University General Hospital,undefined
来源：
Acta Pharmacologica Sinica | 2009年 / 30卷
关键词：
isothiocyanate; chemoprevention; anticarcinogenic; antitumor; apoptosis; cell cycle;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
Isothiocyanates are naturally occurring small molecules that are formed from glucosinolate precursors of cruciferous vegetables. Many isothiocyanates, both natural and synthetic, display anticarcinogenic activity because they reduce activation of carcinogens and increase their detoxification. Recent studies show that they exhibit anti-tumor activity by affecting multiple pathways including apoptosis, MAPK signaling, oxidative stress, and cell cycle progression. This review summarizes the current knowledge on isothiocyanates and focuses on their role as potential anti-cancer agents.
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页码：501 / 512
页数：11
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