Targeting ferroptosis in breast cancer

被引：0
作者：
Zhaoqing Li
Lini Chen
Cong Chen
Yulu Zhou
Dengdi Hu
Jingjing Yang
Yongxia Chen
Wenying Zhuo
Misha Mao
Xun Zhang
Ling Xu
Linbo Wang
Jichun Zhou
机构：
[1] Zhejiang University,Department of Surgical Oncology, Sir Run Run Shaw Hospital
[2] Zhejiang University,Cancer Institute (Key Laboratory of Cancer Prevention and Intervention, China National Ministry of Education), 2nd Affiliated Hospital, School of Medicine
[3] Biomedical Research Center and Key Laboratory of Biotherapy of Zhejiang Province,undefined
[4] Cixi People’s Hospital Medical and Health Group,undefined
来源：
Biomarker Research | / 8卷
关键词：
Ferroptosis; Breast cancer; Regulated cell death; Crosstalk; Ferroptotic regulators; Historical perspective;
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摘要：
Ferroptosis is a recently discovered distinct type of regulated cell death caused by the accumulation of lipid-based ROS. Metabolism and expression of specific genes affect the occurrence of ferroptosis, making it a promising therapeutic target to manage cancer. Here, we describe the current status of ferroptosis studies in breast cancer and trace the key regulators of ferroptosis back to previous studies. We also compare ferroptosis to common regulated cell death patterns and discuss the sensitivity to ferroptosis in different subtypes of breast cancer. We propose that viewing ferroptosis-related studies from a historical angle will accelerate the development of ferroptosis-based biomarkers and therapeutic strategies in breast cancer.
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[71]  
Zhang S(2020)Ferroptosis: A Regulated Cell Death Nexus Linking Metabolism, Redox Biology, and Disease Front Pharmacol 11 239-1494
[72]  
Wen Z(2016)Ferroptosis and Its Potential Role in Human Diseases J Neurochem 139 179-4297
[73]  
Dong S(2015)Iron neurochemistry in Alzheimer’s disease and Parkinson’s disease: targets for therapeutics J Biol Chem 290 28097-12748
[74]  
Rao J(2017)Ablation of the Ferroptosis Inhibitor Glutathione Peroxidase 4 in Neurons Results in Rapid Motor Neuron Degeneration and Paralysis Nature 551 639-563
[75]  
Ma S(2019)NFS1 undergoes positive selection in lung tumours and protects cells from ferroptosis Oncol Rep 42 826-20
[76]  
Henson ES(2017)Sulfasalazine induced ferroptosis in breast cancer cells is reduced by the inhibitory effect of estrogen receptor on the transferrin receptor Nature 551 247-326
[77]  
Chen Y(2017)Drug-tolerant persister cancer cells are vulnerable to GPX4 inhibition Oncotarget 8 114588-5620
[78]  
Gibson SB(2019)CHAC1 degradation of glutathione enhances cystine-starvation-induced necroptosis and ferroptosis in human triple negative breast cancer cells via the GCN2-eIF2alpha-ATF4 pathway Oncol Rep 42 826-363
[79]  
Dolma S(2019)Sulfasalazineinduced ferroptosis in breast cancer cells is reduced by the inhibitory effect of estrogen receptor on the transferrin receptor Dev Cell 51 575-53
[80]  
Lessnick SL(2019)Prominin2 Drives Ferroptosis Resistance by Stimulating Iron Export Free Radic Biol Med 133 162-5150
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