Targeting ferroptosis in breast cancer

被引：0
作者：
Zhaoqing Li
Lini Chen
Cong Chen
Yulu Zhou
Dengdi Hu
Jingjing Yang
Yongxia Chen
Wenying Zhuo
Misha Mao
Xun Zhang
Ling Xu
Linbo Wang
Jichun Zhou
机构：
[1] Zhejiang University,Department of Surgical Oncology, Sir Run Run Shaw Hospital
[2] Zhejiang University,Cancer Institute (Key Laboratory of Cancer Prevention and Intervention, China National Ministry of Education), 2nd Affiliated Hospital, School of Medicine
[3] Biomedical Research Center and Key Laboratory of Biotherapy of Zhejiang Province,undefined
[4] Cixi People’s Hospital Medical and Health Group,undefined
来源：
Biomarker Research | / 8卷
关键词：
Ferroptosis; Breast cancer; Regulated cell death; Crosstalk; Ferroptotic regulators; Historical perspective;
D O I：
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摘要：
Ferroptosis is a recently discovered distinct type of regulated cell death caused by the accumulation of lipid-based ROS. Metabolism and expression of specific genes affect the occurrence of ferroptosis, making it a promising therapeutic target to manage cancer. Here, we describe the current status of ferroptosis studies in breast cancer and trace the key regulators of ferroptosis back to previous studies. We also compare ferroptosis to common regulated cell death patterns and discuss the sensitivity to ferroptosis in different subtypes of breast cancer. We propose that viewing ferroptosis-related studies from a historical angle will accelerate the development of ferroptosis-based biomarkers and therapeutic strategies in breast cancer.
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[11]  
Zaitsev EM(2017)The retinoblastoma (Rb) protein regulates ferroptosis induced by sorafenib in human hepatocellular carcinoma cells Neoplasia 19 1022-245
[12]  
Gleason CE(2016)Cysteine Dioxygenase 1 Mediates Erastin-Induced Ferroptosis in Human Gastric Cancer Cells Cell Death Dis 7 e2307-176
[13]  
Patel DN(2003)Ferroptosis is induced following siramesine and lapatinib treatment of breast cancer cells Cancer Cell 3 285-98
[14]  
Bauer AJ(2008)Identification of genotype-selective antitumor agents using synthetic lethal chemical screening in engineered human tumor cells Chem Biol 15 234-425
[15]  
Cantley AM(2016)Synthetic lethal screening identifies compounds activating iron-dependent, nonapoptotic cell death in oncogenic-RAS-harboring cancer cells Trends Cell Biol 26 165-657
[16]  
Yang WS(2017)Ferroptosis: Death by Lipid Peroxidation Nat Chem Biol 13 91-364
[17]  
Li J(2017)ACSL4 dictates ferroptosis sensitivity by shaping cellular lipid composition Biochem Biophys Res Commun 482 419-331
[18]  
Cao F(2017)Lipid peroxidation in cell death J Cell Mol Med 21 648-1704
[19]  
Yin HL(2019)Ferroptosis, a new form of cell death, and its relationships with tumourous diseases Front Physiol 10 139-62
[20]  
Huang ZJ(2019)Mechanisms of Ferroptosis and Relations With Regulated Cell Death: A Review Cell Res 29 347-575
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