Acute Kidney Injury in Acute on Chronic Liver Failure Versus Decompensated Cirrhosis—What Is the Difference?

被引：0
作者：
Singh S.P. [1 ]
Madke T. [1 ]
Maiwall R. [1 ]
机构：
[1] Department of Hepatology, Institute of Liver and Biliary Sciences, Vasant Kunj, New Delhi
来源：
Current Hepatology Reports | 2024年 / 23卷 / 2期
关键词：
ACLF; AKI; Cirrhosis; Hepatorenal syndrome;
D O I：
10.1007/s11901-024-00660-9
中图分类号：
学科分类号：
摘要：
Purpose of Review: Hepatorenal syndrome (HRS), the severe manifestation of renal injury in patients with cirrhosis and acute on chronic liver failure (ACLF), is characterized by decreased renal blood flow and glomerular filtration rate. Manuscript will elaborate how acute kidney injury (AKI) is different in ACLF and cirrhosis. Recent Findings: We have role of biomarkers in differentiating HRS AKI from chronic kidney disease (CKD) in cirrhosis as well as ACLF patients. Medical therapy, timing of extracorporeal therapies, and role of liver transplant in patients of cirrhosis and ACLF. Summary: ACLF patients usually have structural form of AKI as compared to functional-volume responsive AKI in patients with cirrhosis. Combination of terlipressin and albumin augments renal recovery faster than other vasopressor therapies. But, liver transplant always remain the definitive treatment of progressive renal failure in patients with cirrhosis as well as ACLF. © The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature 2024.
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页码：294 / 305
页数：11
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