Acute Kidney Injury in Acute on Chronic Liver Failure Versus Decompensated Cirrhosis-What Is the Difference?

被引：0

作者：

Singh, Satender Pal ^{[1
]}

Madke, Tushar ^{[1
]}

Maiwall, Rakhi ^{[1
]}

机构：

[1] Inst Liver & Biliary Sci, Dept Hepatol, New Delhi 110070, India

来源：

CURRENT HEPATOLOGY REPORTS | 2024年 / 23卷 / 02期

关键词：

Hepatorenal syndrome; AKI; Cirrhosis; ACLF; TERLIPRESSIN PLUS ALBUMIN; HEPATORENAL-SYNDROME; RENAL-FUNCTION; CYSTATIN C; NORADRENALINE; PREDICTOR; BIOMARKER; PROTEIN; DISEASE; TRIAL;

D O I：

10.1007/s11901-024-00660-9

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

Purpose of ReviewHepatorenal syndrome (HRS), the severe manifestation of renal injury in patients with cirrhosis and acute on chronic liver failure (ACLF), is characterized by decreased renal blood flow and glomerular filtration rate. Manuscript will elaborate how acute kidney injury (AKI) is different in ACLF and cirrhosis.Recent FindingsWe have role of biomarkers in differentiating HRS AKI from chronic kidney disease (CKD) in cirrhosis as well as ACLF patients. Medical therapy, timing of extracorporeal therapies, and role of liver transplant in patients of cirrhosis and ACLF.SummaryACLF patients usually have structural form of AKI as compared to functional-volume responsive AKI in patients with cirrhosis. Combination of terlipressin and albumin augments renal recovery faster than other vasopressor therapies. But, liver transplant always remain the definitive treatment of progressive renal failure in patients with cirrhosis as well as ACLF.

引用

页码：294 / 305

页数：12

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