Potential and Capabilities of Porous Silicon as a Material for Intravascular Drug-Eluting Stents: Brief Summary

被引：2
作者：
Kashin O.A. [1 ]
Krukovskii K.V. [1 ]
Lotkov A.I. [1 ]
机构：
[1] Institute of Strength Physics and Materials Science, Siberian Branch, Russian Academy of Sciences, Tomsk
来源：
Inorganic Materials: Applied Research | 2020年 / 11卷 / 02期
关键词：
drug-containing coating; intravascular drug-eluting stents; porous silicon;
D O I：
10.1134/S2075113320020161
中图分类号：
学科分类号：
摘要：
Abstract: In search for a drug-containing material when creating polymer-free drug-eluting stents, an analysis of the available literature is carried out. It is shown that one of the promising materials for this purpose is mesoporous silicon (the cross-sectional pore diameter is 2–50 nm), which has high biocompatibility and biodegradability. The main requirements for the porous silicon coating as a drug carrier of metal intravascular stents are formulated. The results of experimental studies are presented, including those performed by the authors, showing the possibility of continuous silicon coating application up to 0.6 μm thick on the stents by magnetron sputtering or plasma-immersion ion implantation and deposition (PIII@D). These methods provide high coating adhesion to the stent material and allow coating both on the external and internal stent surfaces. © 2020, Pleiades Publishing, Ltd.
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页码：287 / 296
页数：9
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