Plasma manganese, selenium, zinc, copper, and iron concentrations in patients with schizophrenia

被引:0
作者
Medaim Yanik
Abdurrahim Kocyigit
Hamdi Tutkun
Huseyin Vural
Hasan Herken
机构
[1] University of Harran,Department of Psychiatry
[2] University of Harran,Department of Biochemistry, Faculty of Medicine
[3] University of Gaziantep,Department of Psychiatry, Faculty of Medicine
来源
Biological Trace Element Research | 2004年 / 98卷
关键词
Schizophrenia; manganese; selenium; zinc; copper; iron;
D O I
暂无
中图分类号
学科分类号
摘要
A number of essential trace elements play a major role in various metabolic pathways. Selenium (Se), manganese (Mn), copper (Cu), zinc (Zn), and iron (Fe) are essential trace elements that have been studied in many diseases, including autoimmune, neurological, and psychiatric disorders. However, the findings of previous research on the status of trace elements in patients with schizophrenia have been controversial. We studied these elements in patients with a DSM-IV diagnosis of schizophrenia and compared them with sex- and age-matched healthy controls. Plasma Cu concentrations were significantly higher (p<0.01) and Mn and Fe concentrations were lower (p<0.05 and p<0.05, respectively) in schizophrenic patients than in controls. Se and Zn concentrations and protein levels did not differ between patients and healthy controls. These observations suggest that alterations in essential trace elements Mn, Cu, and Fe may play a role in the pathogenesis of schizophrenia. However, findings from trace element levels in schizophrenia show a variety of results that are difficult to interpret.
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页码:109 / 117
页数:8
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