Targeting the Sodium-Dependent Multivitamin Transporter (SMVT) for Improving the Oral Absorption Properties of a Retro-Inverso Tat Nonapeptide

被引：0
作者：
Srinivasan Ramanathan
Shahriar Pooyan
Stanley Stein
Puttur D. Prasad
Jihong Wang
Michael J. Leibowitz
Vadivel Ganapathy
Patrick J. Sinko
机构：
[1] The State University of New Jersey,College of Pharmacy, Rutgers
[2] Center for Advanced Biotechnology and Medicine (CABM),Department of Chemistry, Rutgers
[3] The State University of New Jersey,Department of Obstetrics and Gynecology
[4] University of Medicine and Dentistry of New Jersey,undefined
[5] Robert Wood Johnson Medical School,undefined
[6] Medical College of Georgia,undefined
[7] Cancer Institute of New Jersey,undefined
[8] Center for Biomaterials (CBM),undefined
来源：
Pharmaceutical Research | 2001年 / 18卷
关键词：
Tat peptide; oral absorption; biotin; vitamin transporter; Caco-2; CHO;
D O I：
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中图分类号：
学科分类号：
摘要：
Purpose. To investigate the potential for delivering large peptides orally by altering their absorptive transport pathways and improving intestinal permeability. The absorptive transport of retro-inverso (R.I.-) K-Tat9 and R.I.-K(biotin)-Tat9, novel peptidic inhibitors of the Tat protein of HIV-1, and their interactions with human SMVT (hSMVT), a high affinity, low capacity transporter, were investigated using Caco-2 and transfected CHO cells.
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页码：950 / 956
页数：6
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